TitleTissue fatty acid changes and tumor incidence in C3H mice ingesting cottonseed oil.
Publication TypeJournal Article
Year of Publication1982
AuthorsTinsley IJ, Lowry RR
Date Published1982 Feb
Animals, Cottonseed Oil, Fatty Acids, Female, Mammary Glands, Animal, Mammary Neoplasms, Experimental, Mice, Mice, Inbred C3H, Triglycerides

The incidence of spontaneous mammary tumors in C3H mice at 35 wk was higher in mice fed rations containing cottonseed oil than in mice fed fats of comparable fatty acid composition. The time to 50% (T50) incidence was also shorter in the first group. The fatty acid composition of tissue lipids from mice fed the cottonseed oil showed changes indicating the presence of cyclopropene fatty acids-higher levels of saturates and lower oleate/stearate and palmitoleate/palmitate ratios. A possible association between the development of a spontaneous mammary tumor in the C3H mouse and the presence of cyclopropene fatty acids in the cottonseed oil is indicated.

Alternate JournalLipids
PubMed ID6896358
Grant ListCA20998 / CA / NCI NIH HHS / United States