Title | Developmental exposure to polychlorinated biphenyls interferes with experience-dependent dendritic plasticity and ryanodine receptor expression in weanling rats. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Yang D, Kim K H, Phimister A, Bachstetter AD, Ward TR, Stackman RW, Mervis RF, Wisniewski AB, Klein SL, Kodavanti P RS, Anderson KA, Wayman G, Pessah IN, Lein PJ |
Journal | Environ Health Perspect |
Volume | 117 |
Issue | 3 |
Pagination | 426-35 |
Date Published | 03/2009 |
ISSN | 1552-9924 |
Animals, Animals, Newborn, Body Weight, Chlorodiphenyl (54% Chlorine), Dendrites, Female, Gene Expression Regulation, Developmental, Green Fluorescent Proteins, Litter Size, Maze Learning, Memory, Microtubule-Associated Proteins, Neuronal Plasticity, Pregnancy, Prenatal Exposure Delayed Effects, Rats, Rats, Sprague-Dawley, Ryanodine Receptor Calcium Release Channel, Sex Ratio | |
BACKGROUND: Neurodevelopmental disorders are associated with altered patterns of neuronal connectivity. A critical determinant of neuronal connectivity is the dendritic morphology of individual neurons, which is shaped by experience. The identification of environmental exposures that interfere with dendritic growth and plasticity may, therefore, provide insight into environmental risk factors for neurodevelopmental disorders. | |
10.1289/ehp.11771 | |
Alternate Journal | Environ. Health Perspect. |
PubMed ID | 19337518 |
PubMed Central ID | PMC2661913 |
Grant List | 1P01ES11269 / ES / NIEHS NIH HHS / United States GM041292 / GM / NIGMS NIH HHS / United States HD40936 / HD / NICHD NIH HHS / United States NS046649 / NS / NINDS NIH HHS / United States P01 ES011269 / ES / NIEHS NIH HHS / United States R01 ES014901 / ES / NIEHS NIH HHS / United States R01 NS046649 / NS / NINDS NIH HHS / United States R03 HD040936 / HD / NICHD NIH HHS / United States |