TitleExploiting lipid-free tubing passive samplers and embryonic zebrafish to link site specific contaminant mixtures to biological responses.
Publication TypeJournal Article
Year of Publication2010
AuthorsHillwalker WE, Allan SE, Tanguay RL, Anderson KA
Date Published03/2010
Animals, Embryo, Nonmammalian, Embryonic Development, Environmental Monitoring, Lipids, Rivers, Water Pollutants, Chemical, Zebrafish

The Biological Response Indicator Devices Gauging Environmental Stressors (BRIDGES) bio-analytical tool was developed in response to the need for a quantitative technology for assessing the toxicity of environmentally relevant contaminant mixtures. This tool combines passive samplers with the embryonic zebrafish model. When applied in an urban river it effectively linked site specific, bioavailable contaminant mixtures to multiple biological responses. Embryonic zebrafish exposed to extracts from lipid-free passive samplers that were deployed at five locations, within and outside of the Portland Harbor Superfund Megasite, displayed different responses. Six of the eighteen biological responses observed in 941 exposed zebrafish were significantly different between sites. This demonstrates the sensitivity of the bio-analytical tool for detecting spatially distinct toxicity in aquatic systems; bridging environmental exposure to biological response.

Alternate JournalChemosphere
PubMed ID20172587
PubMed Central IDPMC2833334
Grant ListES00210 / ES / NIEHS NIH HHS / United States
P30 ES000210-39A19017 / ES / NIEHS NIH HHS / United States
P30 ES000210-409017 / ES / NIEHS NIH HHS / United States
P42 ES016465 / ES / NIEHS NIH HHS / United States
P42 ES016465-01A16112 / ES / NIEHS NIH HHS / United States
P42 ES016465-01A16113 / ES / NIEHS NIH HHS / United States
P42 ES016465-026112 / ES / NIEHS NIH HHS / United States
T32 ES007060 / ES / NIEHS NIH HHS / United States
T32 ES007060-33 / ES / NIEHS NIH HHS / United States
Projects Reference: 
Portland Harbor
LDPE Passive Sampling Devices