<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kathleen Mullen</style></author><author><style face="normal" font="default" size="100%">Briana N Rivera</style></author><author><style face="normal" font="default" size="100%">Lane G Tidwell</style></author><author><style face="normal" font="default" size="100%">Renata Ivanek</style></author><author><style face="normal" font="default" size="100%">Kim A Anderson</style></author><author><style face="normal" font="default" size="100%">Dorothy Ainsworth</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Environmental surveillance and adverse neonatal health outcomes in foals born near unconventional natural gas development activity.</style></title><secondary-title><style face="normal" font="default" size="100%">Sci Total Environ</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Sci. Total Environ.</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals, Newborn</style></keyword><keyword><style  face="normal" font="default" size="100%">Environmental Monitoring</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Horses</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Infant, Newborn</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural Gas</style></keyword><keyword><style  face="normal" font="default" size="100%">New York</style></keyword><keyword><style  face="normal" font="default" size="100%">Outcome Assessment, Health Care</style></keyword><keyword><style  face="normal" font="default" size="100%">Pennsylvania</style></keyword><keyword><style  face="normal" font="default" size="100%">Pregnancy</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2020 Aug 20</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">731</style></volume><pages><style face="normal" font="default" size="100%">138497</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Studies of neonatal health risks of unconventional natural gas development (UNGD) have not included comprehensive assessments of environmental chemical exposures. We investigated a clustering of dysphagic cases in neonatal foals born between 2014 and 2016 in an area of active UNGD in Pennsylvania (PA),USA. We evaluated equine biological data and environmental exposures on the affected PA farm and an unaffected New York (NY) farm owned by the same proprietor. Dams either spent their entire gestation on one farm or moved to the other farm in late gestation. Over the 21-month study period, physical examinations and blood/tissue samples were obtained from mares and foals on each farm. Grab samples of water, pasture soil and feed were collected; continuous passive sampling of air and water for polycyclic aromatic hydrocarbons was performed. Dysphagia was evaluated as a binary variable; logistic regression was used to identify risk factors. Sixty-five foals were born, 17 (all from PA farm) were dysphagic. Odds of dysphagia increased with the dam residing on the PA farm for each additional month of gestation (OR&amp;nbsp;=&amp;nbsp;1.4, 95% CI 1.2, 1.7, p&amp;nbsp;=&amp;nbsp;6.0E-04). Males were more likely to be born dysphagic (OR&amp;nbsp;=&amp;nbsp;5.5, 95% CI 1.2, 24.5, p&amp;nbsp;=&amp;nbsp;0.03) than females. Prior to installation of a water filtration/treatment system, PA water concentrations of 3,6-dimethylphenanthrene (p&amp;nbsp;=&amp;nbsp;6.0E-03), fluoranthene (p&amp;nbsp;=&amp;nbsp;0.03), pyrene (p&amp;nbsp;=&amp;nbsp;0.02) and triphenylene (p&amp;nbsp;=&amp;nbsp;0.01) exceeded those in NY water. Compared to NY farm water, no concentrations of PAHs were higher in PA following installation of the water filtration/treatment system. We provide evidence of an uncommon adverse health outcome (dysphagia) in foals born near UNGD that was eliminated in subsequent years (2017-2019) following environmental management changes. Notably, this study demonstrates that domestic large animals such as horses can serve as important sentinels for human health risks associated with UNGD activities.&lt;/p&gt;
</style></abstract></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>3</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Briana N Rivera</style></author><author><style face="normal" font="default" size="100%">Kathleen Mullen</style></author><author><style face="normal" font="default" size="100%">Lane G Tidwell</style></author><author><style face="normal" font="default" size="100%">Renata Ivanek</style></author><author><style face="normal" font="default" size="100%">Dorothy Ainsworth</style></author><author><style face="normal" font="default" size="100%">Susan C Tilton</style></author><author><style face="normal" font="default" size="100%">Kim A Anderson</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Determining Environmental Exposure Profiles of Health and Dysphagic Foals</style></title><secondary-title><style face="normal" font="default" size="100%">Society of Environmental Toxicology and Chemistry North America, Toronto, ON</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">11/2019</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>3</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Briana N Rivera</style></author><author><style face="normal" font="default" size="100%">Kathleen Mullen</style></author><author><style face="normal" font="default" size="100%">Lane G Tidwell</style></author><author><style face="normal" font="default" size="100%">Renata Ivanek</style></author><author><style face="normal" font="default" size="100%">Dorothy Ainsworth</style></author><author><style face="normal" font="default" size="100%">Susan C Tilton</style></author><author><style face="normal" font="default" size="100%">Kim A Anderson</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Determining Environmental Exposure Profiles of Health and Dysphagic Foals</style></title><secondary-title><style face="normal" font="default" size="100%">Superfund Research Program, Seattle, WA</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">11/2019</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>3</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Briana N Rivera</style></author><author><style face="normal" font="default" size="100%">Lane G Tidwell</style></author><author><style face="normal" font="default" size="100%">Carey E Donald</style></author><author><style face="normal" font="default" size="100%">Yvonne Chang</style></author><author><style face="normal" font="default" size="100%">Kathleen Mullen</style></author><author><style face="normal" font="default" size="100%">Dorothy Ainsworth</style></author><author><style face="normal" font="default" size="100%">Kim A Anderson</style></author><author><style face="normal" font="default" size="100%">Susan C Tilton</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluating Toxicity of Inhalation Exposure to Unconventional Natural Gas Drilling</style></title><secondary-title><style face="normal" font="default" size="100%">Society of Toxicology National Conference, Baltimore, MD</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">03/2019</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>3</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Briana N Rivera</style></author><author><style face="normal" font="default" size="100%">Lane G Tidwell</style></author><author><style face="normal" font="default" size="100%">Carey E Donald</style></author><author><style face="normal" font="default" size="100%">Yvonne Chang</style></author><author><style face="normal" font="default" size="100%">Kathleen Mullen</style></author><author><style face="normal" font="default" size="100%">Dorothy Ainsworth</style></author><author><style face="normal" font="default" size="100%">Kim A Anderson</style></author><author><style face="normal" font="default" size="100%">Susan C Tilton</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluating Toxicity of Inhalation Exposure to Unconventional Natural Gas Drilling</style></title><secondary-title><style face="normal" font="default" size="100%">Society of Toxicology National Conference, Baltimore, MD</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">03/2019</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>13</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Briana N Rivera</style></author><author><style face="normal" font="default" size="100%">Kathleen Mullen</style></author><author><style face="normal" font="default" size="100%">Lane G Tidwell</style></author><author><style face="normal" font="default" size="100%">Renata Ivanek</style></author><author><style face="normal" font="default" size="100%">Dorothy Ainsworth</style></author><author><style face="normal" font="default" size="100%">Susan C Tilton</style></author><author><style face="normal" font="default" size="100%">Kim A Anderson</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Using Passive Samplers to Evaluate Inhalation Exposure</style></title><secondary-title><style face="normal" font="default" size="100%">Military Health System Research Symposium, Kissimmee, FL</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">08/2019</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>3</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Briana N Rivera</style></author><author><style face="normal" font="default" size="100%">Lane G Tidwell</style></author><author><style face="normal" font="default" size="100%">Yvonne Chang</style></author><author><style face="normal" font="default" size="100%">Carey E Donald</style></author><author><style face="normal" font="default" size="100%">Kathleen Mullen</style></author><author><style face="normal" font="default" size="100%">Dorothy Ainsworth</style></author><author><style face="normal" font="default" size="100%">Richard P Scott</style></author><author><style face="normal" font="default" size="100%">Kim A Anderson</style></author><author><style face="normal" font="default" size="100%">Susan C Tilton</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluating Toxicity Associated with Inhalation Exposure to Unconventional Natural Gas Drilling</style></title><secondary-title><style face="normal" font="default" size="100%">Environmental Public Health in the 21st Century Research Symposium</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2018</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>3</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Briana N Rivera</style></author><author><style face="normal" font="default" size="100%">Lane G Tidwell</style></author><author><style face="normal" font="default" size="100%">Carey E Donald</style></author><author><style face="normal" font="default" size="100%">Kathleen Mullen</style></author><author><style face="normal" font="default" size="100%">Dorothy Ainsworth</style></author><author><style face="normal" font="default" size="100%">Richard P Scott</style></author><author><style face="normal" font="default" size="100%">Kim A Anderson</style></author><author><style face="normal" font="default" size="100%">Susan C Tilton</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Using passive samplers and 3D bronchial epithelium to determine toxicity associated with natural gas drilling</style></title><secondary-title><style face="normal" font="default" size="100%">Center for Genome Research and Biocomputing Fall Conference</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">10/2018</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>3</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Briana N Rivera</style></author><author><style face="normal" font="default" size="100%">Lane G Tidwell</style></author><author><style face="normal" font="default" size="100%">Carey E Donald</style></author><author><style face="normal" font="default" size="100%">Kathleen Mullen</style></author><author><style face="normal" font="default" size="100%">Dorothy Ainsworth</style></author><author><style face="normal" font="default" size="100%">Richard P Scott</style></author><author><style face="normal" font="default" size="100%">Kim A Anderson</style></author><author><style face="normal" font="default" size="100%">Susan C Tilton</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Using passive samplers and 3D bronchial epithelium to determine toxicity associated with natural gas drilling </style></title><secondary-title><style face="normal" font="default" size="100%">Pacific Northwest Association of Toxicologists (PANWAT), Bothell, Wa</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">10/2018</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>13</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lane G Tidwell</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Carey E Donald</style></author><author><style face="normal" font="default" size="100%">Kathleen Mullen</style></author><author><style face="normal" font="default" size="100%">Kim A Anderson</style></author></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Leveraging passive sampling and unique equine population exposures to assess negative post-natal health outcomes</style></title><secondary-title><style face="normal" font="default" size="100%">International Society of Exposure Science</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">10/2017</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;In 2012 a high prevalence of neonatal foals born with neurological deficits (altered mentation and dysphagia) was observed at a farm located in Pennsylvania (PA) near a number of unconventional natural gas drilling (UNGD) sites.&amp;nbsp; The farm proprietor also owned another horse farm in New York (NY) that was not situated near UNGD sites. Newborn foals and mares on the NY farm did not exhibit similar health issues. Over the last 5 years the frequency of dysphagia in foals at the PA facility has increased from 25 to 92%.&amp;nbsp; From 2014 to 2016 passive sampling devices (PSDs) were deployed on brood mares at both farms continually, and PSDs were changed out every six weeks. PSDs were also deployed in the ambient air and in well water at each farm. .&amp;nbsp;&lt;/p&gt;
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