<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Christian I Rude</style></author><author><style face="normal" font="default" size="100%">Jordan Smith</style></author><author><style face="normal" font="default" size="100%">Richard P Scott</style></author><author><style face="normal" font="default" size="100%">Katherine J Schultz</style></author><author><style face="normal" font="default" size="100%">Kim A Anderson</style></author><author><style face="normal" font="default" size="100%">Robyn L Tanguay</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A mixture parameterized biologically based dosimetry model to predict body burdens of polycyclic aromatic hydrocarbons in developmental zebrafish toxicity assays</style></title><secondary-title><style face="normal" font="default" size="100%">Toxicological Sciences</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">In Press</style></year><pub-dates><date><style  face="normal" font="default" size="100%">03/2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">205</style></volume><pages><style face="normal" font="default" size="100%">326-343</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Polycyclic aromatic hydrocarbons (PAHs) are a group of environmental toxicants found ubiquitously as complex mixtures in human-impacted environments. Developmental zebrafish exposures have been used widely to study PAH toxicity, but most studies report nominal exposure concentrations. Nominal exposure concentrations can be unreliable dose metrics due to differences in toxicant bioavailability resulting from disparate exposure methodologies and chemical properties. Toxicokinetic modeling can predict toxicant tissue doses to facilitate comparison between exposures of different chemicals, methodologies, and biological models. We parameterize a biologically based dosimetry model for developmental zebrafish toxicity assays for 9 PAHs. The model was optimized with measurements from media, tissue, and plastic plate walls throughout a static developmental exposure to a mixture of 10 PAHs of high abundance within the Portland Harbor Superfund Site. Plate binding, volatilization, zebrafish permeability, and tissue—media partitioning coefficients vary widely between PAHs. Model predictions accounted for 83% and 54% of 48 hpf body burdens within a factor of 2 resulting from exposures to mixtures and individual PAHs, respectively. Accounting for solubility significantly improves model performance. Competition for active sites in metabolizing enzymes may change biotransformation kinetics between individual PAH and mixture exposures. Area under the curve estimations of concentrations in zebrafish resulted in altered hazard rankings from nominal exposure concentrations. Future work will be oriented to generalizing the model to other PAHs. This PAH dosimetry model improves the interpretability of developmental zebrafish toxicity assays by providing time-resolved body burdens from nominal exposure concentrations.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><section><style face="normal" font="default" size="100%">326</style></section></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>3</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kelly E O&#039;Malley</style></author><author><style face="normal" font="default" size="100%">Christine C Ghetu</style></author><author><style face="normal" font="default" size="100%">Diana Rohlman</style></author><author><style face="normal" font="default" size="100%">Brian W Smith</style></author><author><style face="normal" font="default" size="100%">Richard P Scott</style></author><author><style face="normal" font="default" size="100%">Kaley A Adams</style></author><author><style face="normal" font="default" size="100%">Peter D Hoffman</style></author><author><style face="normal" font="default" size="100%">Kim A Anderson</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Movement of PAHs and Alkylated PAHs Between Air and Soil Pre-Wildfire, Wildfire, and Post-Wildfire</style></title><secondary-title><style face="normal" font="default" size="100%">OSU EMT Research Day Symposium Corvallis, OR</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2023</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>3</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kelly E O&#039;Malley</style></author><author><style face="normal" font="default" size="100%">Christine C Ghetu</style></author><author><style face="normal" font="default" size="100%">Diana Rohlman</style></author><author><style face="normal" font="default" size="100%">Brian W Smith</style></author><author><style face="normal" font="default" size="100%">Richard P Scott</style></author><author><style face="normal" font="default" size="100%">Kaley A Adams</style></author><author><style face="normal" font="default" size="100%">Peter D Hoffman</style></author><author><style face="normal" font="default" size="100%">Kim A Anderson</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Movement of Parent PAHs and Alkylated PAHs Between Air and Soil Before, During, and After a Wildfire</style></title><secondary-title><style face="normal" font="default" size="100%">PNW SETAC 32nd Annual Conference Troutdale, OR</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">05/2023</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>3</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kelly E O&#039;Malley</style></author><author><style face="normal" font="default" size="100%">Christine C Ghetu</style></author><author><style face="normal" font="default" size="100%">Diana Rohlman</style></author><author><style face="normal" font="default" size="100%">Brian W Smith</style></author><author><style face="normal" font="default" size="100%">Richard P Scott</style></author><author><style face="normal" font="default" size="100%">Kaley A Adams</style></author><author><style face="normal" font="default" size="100%">Peter D Hoffman</style></author><author><style face="normal" font="default" size="100%">Kim A Anderson</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Movement of PAHs and Alkylated PAHs Between Air and Soil Before, During, and After Wildfires</style></title><secondary-title><style face="normal" font="default" size="100%">SETAC North America 43rd Annual Meeting Pittsburgh, PA</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">11/2022</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>13</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">LB Paulik</style></author><author><style face="normal" font="default" size="100%">Kevin A Hobbie</style></author><author><style face="normal" font="default" size="100%">Diana Rohlman</style></author><author><style face="normal" font="default" size="100%">Smith BW</style></author><author><style face="normal" font="default" size="100%">Richard P Scott</style></author><author><style face="normal" font="default" size="100%">Laurel D Kincl</style></author><author><style face="normal" font="default" size="100%">Haynes EN</style></author><author><style face="normal" font="default" size="100%">Kim A Anderson</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Movement of PAHs emitted from natural gas extraction wells</style></title><secondary-title><style face="normal" font="default" size="100%">International Society of Exposure Science 26th Annual Meeting, Utrecht, The Netherlands</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">10/2016</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>3</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kevin A Hobbie</style></author><author><style face="normal" font="default" size="100%">Richard P Scott</style></author><author><style face="normal" font="default" size="100%">Diana Rohlman</style></author><author><style face="normal" font="default" size="100%">Laurel D Kincl</style></author><author><style face="normal" font="default" size="100%">Scaffidi, Chris</style></author><author><style face="normal" font="default" size="100%">Elena S Peterson</style></author><author><style face="normal" font="default" size="100%">Katrina M Waters</style></author><author><style face="normal" font="default" size="100%">Kim A Anderson</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Mobile Exposure Device: a Personal Sampling Nexus for Exposure Monitoring</style></title><secondary-title><style face="normal" font="default" size="100%">Society of Environmental Toxicology and Chemistry North America 34th Annual Meeting, Vancouver, BC, Canada</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">11/2014</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Epidemiological studies linking environmental exposures to health outcomes have been criticized for the lack of personal exposure data. The mobile exposure device (MED) is integrated personal environmental exposure tools coupled with software which links health data to location and chemical exposure. The MED combines a wristband passive sampling device with a smart phone application and biometric equipment providing a holistic tool to capture uniquely linked environmental-health information.&amp;nbsp; Silicone passive sampling wristbands sequester organic compounds while a cell phone application captures geographic location of study participants. Users were prompted to test lung function with a spirometer three times daily to identify variation in lung function throughout a typical daily routine.&amp;nbsp; Wristbands were worn daily then mailed to the laboratory, extracted, and analyzed for over 1,200 organic compounds including PAHs, OPAHs, PCBs, pesticides, flame retardants and industrial chemicals. Data is transmitted securely from a laboratory information management system and the smart phone app to a secure server through web services and integrated in order to discover statistical relationships among air pollutants, locations, and lung function. The MED was developed and tested in two different exposure scenarios, one community in Oregon with proximity to intense industrial activity, and another community in Ohio near unconventional natural gas drilling operations. Focus group meetings were employed in both communities to further enhance and optimize the MED. Early beta testing resulted in a daily accumulation of over 600,000 data points including geographic location, lung function, and chemical observations for each participant. The MED coupled with data integration and visualization techniques will enable researchers &amp;nbsp;to gain new insights and investigate new connections, while allowing communities to see their data in more intuitive ways.&lt;/p&gt;
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