<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Cassandra Lepetit</style></author><author><style face="normal" font="default" size="100%">Mohamed Gaber</style></author><author><style face="normal" font="default" size="100%">Ke Zhou</style></author><author><style face="normal" font="default" size="100%">Haiying Chen</style></author><author><style face="normal" font="default" size="100%">Julia Holmes</style></author><author><style face="normal" font="default" size="100%">Phillip Summers</style></author><author><style face="normal" font="default" size="100%">Kim A Anderson</style></author><author><style face="normal" font="default" size="100%">Richard P Scott</style></author><author><style face="normal" font="default" size="100%">Carey N Pope</style></author><author><style face="normal" font="default" size="100%">Kirstin Hester</style></author><author><style face="normal" font="default" size="100%">Paul J Laurienti</style></author><author><style face="normal" font="default" size="100%">Sara A Quandt</style></author><author><style face="normal" font="default" size="100%">Thomas A Arcury</style></author><author><style face="normal" font="default" size="100%">Pierre‑Alexandre Vidi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Follicular DNA Damage and Pesticide Exposure Among Latinx Children in Rural and Urban Communities</style></title></titles><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09/2023</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The intersectional risks of children in United States immigrant communities include environmental exposures. Pesticide exposures and their biological outcomes are not well characterized in this population group. We assessed pesticide exposure and related these exposures to DNA double-strand breaks (DSBs) in Latinx children from rural, farmworker families (FW; N = 30) and from urban, non-farmworker families (NFW; N = 15) living in North Carolina. DSBs were quantified in hair follicular cells by immunostaining of 53BP1, and exposure to 72 pesticides and pesticide degradation products were determined using silicone wristbands. Cholinesterase activity was measured in blood samples. DSB frequencies were higher in FW compared to NFW children. Seasonal effects were detected in the FW group, with highest DNA damage levels in April–June and lowest levels in October–November. Acetylcholinesterase depression had the same seasonality and correlated with follicular DNA damage. Organophosphate pesticides were more frequently detected in FW than in NFW children. Participants with organophosphate detections had increased follicular DNA damage compared to participants without organophosphate detection. Follicular DNA damage did not correlate with organochlorine or pyrethroid detections and was not associated with the total number of pesticides detected in the wristbands. These results point to rural disparities in pesticide exposures and their outcomes in children from vulnerable immigrant communities. They suggest that among the different classes of pesticides, organophosphates have the strongest genotoxic effects. Assessing pesticide exposures and their consequences at the individual level is key to environmental surveillance programs. To this end, the minimally invasive combined approach used here is particularly well suited for children.&lt;/p&gt;
</style></abstract></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Thomas A Arcury</style></author><author><style face="normal" font="default" size="100%">Haiying Chen</style></author><author><style face="normal" font="default" size="100%">Sara A Quandt</style></author><author><style face="normal" font="default" size="100%">Jennifer W Talton</style></author><author><style face="normal" font="default" size="100%">Kim A Anderson</style></author><author><style face="normal" font="default" size="100%">Richard P Scott</style></author><author><style face="normal" font="default" size="100%">Phillip Summers</style></author><author><style face="normal" font="default" size="100%">Paul J Laurienti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pesticide Exposure among Latinx Children in Rural Farmworker and Urban Non-Farmworker Communities: Associations with Locality and Season.</style></title><secondary-title><style face="normal" font="default" size="100%">Int J Environ Res Public Health</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Int J Environ Res Public Health</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Agriculture</style></keyword><keyword><style  face="normal" font="default" size="100%">Child</style></keyword><keyword><style  face="normal" font="default" size="100%">Chlorpyrifos</style></keyword><keyword><style  face="normal" font="default" size="100%">Environmental Exposure</style></keyword><keyword><style  face="normal" font="default" size="100%">Gas Chromatography-Mass Spectrometry</style></keyword><keyword><style  face="normal" font="default" size="100%">Hispanic or Latino</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Pesticides</style></keyword><keyword><style  face="normal" font="default" size="100%">Pyrethrins</style></keyword><keyword><style  face="normal" font="default" size="100%">Seasons</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2023 Apr 26</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">20</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;This study uses repeated measures to document the pesticide exposure of rural and urban Latinx children (age eight at baseline), and to compare these children in terms of the frequency and concentration of their exposure to a large set of pesticides, accounting for season. We used silicone wristbands worn for one week up to ten times at quarterly intervals from 2018 to 2022 to assess pesticide exposure in children from rural farmworker ( = 75) and urban non-farmworker ( = 61) families. We determined the detection and concentrations (ng/g) of 72 pesticides and pesticide degradation products in the wristbands using gas chromatography electron capture detection and gas chromatography mass spectrometry. The most frequently detected pesticide classes were organochlorines, pyrethroids, and organophosphates. Controlling for season, organochlorine or phenylpyrazole detections were less likely for rural children than for urban children. Detections of organochlorines, pyrethroids, or organophosphates were lower in spring and summer versus winter. Controlling for season, urban children had greater concentrations of organochlorines, while rural children had greater concentrations of pyrethroids and Chlorpyrifos. Pesticide concentrations were lower in winter and spring compared with summer and fall. These results further document that pesticides are ubiquitous in the living environment for children in vulnerable, immigrant communities.&lt;/p&gt;
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