<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lepetit, Cassandra</style></author><author><style face="normal" font="default" size="100%">Gaber, Mohamed</style></author><author><style face="normal" font="default" size="100%">Zhou, Ke</style></author><author><style face="normal" font="default" size="100%">Chen, Haiying</style></author><author><style face="normal" font="default" size="100%">Holmes, Julia</style></author><author><style face="normal" font="default" size="100%">Summers, Phillip</style></author><author><style face="normal" font="default" size="100%">Kim A Anderson</style></author><author><style face="normal" font="default" size="100%">Scott, Richard P</style></author><author><style face="normal" font="default" size="100%">Pope, Carey N</style></author><author><style face="normal" font="default" size="100%">Hester, Kirstin</style></author><author><style face="normal" font="default" size="100%">Laurienti, Paul J</style></author><author><style face="normal" font="default" size="100%">Quandt, Sara A</style></author><author><style face="normal" font="default" size="100%">Arcury, Thomas A</style></author><author><style face="normal" font="default" size="100%">Vidi, Pierre-Alexandre</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Follicular DNA Damage and Pesticide Exposure Among Latinx Children in Rural and Urban Communities.</style></title><secondary-title><style face="normal" font="default" size="100%">Expo Health</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Expo Health</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1039-1052</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;UNLABELLED: &lt;/strong&gt;The intersectional risks of children in United States immigrant communities include environmental exposures. Pesticide exposures and their biological outcomes are not well characterized in this population group. We assessed pesticide exposure and related these exposures to DNA double-strand breaks (DSBs) in Latinx children from rural, farmworker families (FW;  = 30) and from urban, non-farmworker families (NFW;  = 15) living in North Carolina. DSBs were quantified in hair follicular cells by immunostaining of 53BP1, and exposure to 72 pesticides and pesticide degradation products were determined using silicone wristbands. Cholinesterase activity was measured in blood samples. DSB frequencies were higher in FW compared to NFW children. Seasonal effects were detected in the FW group, with highest DNA damage levels in April-June and lowest levels in October-November. Acetylcholinesterase depression had the same seasonality and correlated with follicular DNA damage. Organophosphate pesticides were more frequently detected in FW than in NFW children. Participants with organophosphate detections had increased follicular DNA damage compared to participants without organophosphate detection. Follicular DNA damage did not correlate with organochlorine or pyrethroid detections and was not associated with the total number of pesticides detected in the wristbands. These results point to rural disparities in pesticide exposures and their outcomes in children from vulnerable immigrant communities. They suggest that among the different classes of pesticides, organophosphates have the strongest genotoxic effects. Assessing pesticide exposures and their consequences at the individual level is key to environmental surveillance programs. To this end, the minimally invasive combined approach used here is particularly well suited for children.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;SUPPLEMENTARY INFORMATION: &lt;/strong&gt;The online version contains supplementary material available at 10.1007/s12403-023-00609-1.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Cassandra Lepetit</style></author><author><style face="normal" font="default" size="100%">Mohamed Gaber</style></author><author><style face="normal" font="default" size="100%">Ke Zhou</style></author><author><style face="normal" font="default" size="100%">Haiying Chen</style></author><author><style face="normal" font="default" size="100%">Julia Holmes</style></author><author><style face="normal" font="default" size="100%">Phillip Summers</style></author><author><style face="normal" font="default" size="100%">Kim A Anderson</style></author><author><style face="normal" font="default" size="100%">Richard P Scott</style></author><author><style face="normal" font="default" size="100%">Carey N Pope</style></author><author><style face="normal" font="default" size="100%">Kirstin Hester</style></author><author><style face="normal" font="default" size="100%">Paul J Laurienti</style></author><author><style face="normal" font="default" size="100%">Sara A Quandt</style></author><author><style face="normal" font="default" size="100%">Thomas A Arcury</style></author><author><style face="normal" font="default" size="100%">Pierre‑Alexandre Vidi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Follicular DNA Damage and Pesticide Exposure Among Latinx Children in Rural and Urban Communities</style></title></titles><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09/2023</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The intersectional risks of children in United States immigrant communities include environmental exposures. Pesticide exposures and their biological outcomes are not well characterized in this population group. We assessed pesticide exposure and related these exposures to DNA double-strand breaks (DSBs) in Latinx children from rural, farmworker families (FW; N = 30) and from urban, non-farmworker families (NFW; N = 15) living in North Carolina. DSBs were quantified in hair follicular cells by immunostaining of 53BP1, and exposure to 72 pesticides and pesticide degradation products were determined using silicone wristbands. Cholinesterase activity was measured in blood samples. DSB frequencies were higher in FW compared to NFW children. Seasonal effects were detected in the FW group, with highest DNA damage levels in April–June and lowest levels in October–November. Acetylcholinesterase depression had the same seasonality and correlated with follicular DNA damage. Organophosphate pesticides were more frequently detected in FW than in NFW children. Participants with organophosphate detections had increased follicular DNA damage compared to participants without organophosphate detection. Follicular DNA damage did not correlate with organochlorine or pyrethroid detections and was not associated with the total number of pesticides detected in the wristbands. These results point to rural disparities in pesticide exposures and their outcomes in children from vulnerable immigrant communities. They suggest that among the different classes of pesticides, organophosphates have the strongest genotoxic effects. Assessing pesticide exposures and their consequences at the individual level is key to environmental surveillance programs. To this end, the minimally invasive combined approach used here is particularly well suited for children.&lt;/p&gt;
</style></abstract></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vermeulen, Roel</style></author><author><style face="normal" font="default" size="100%">Downward, George S</style></author><author><style face="normal" font="default" size="100%">Zhang, Jinming</style></author><author><style face="normal" font="default" size="100%">Hu, Wei</style></author><author><style face="normal" font="default" size="100%">Portengen, Lützen</style></author><author><style face="normal" font="default" size="100%">Bassig, Bryan A</style></author><author><style face="normal" font="default" size="100%">Hammond, S Katharine</style></author><author><style face="normal" font="default" size="100%">Wong, Jason Y Y</style></author><author><style face="normal" font="default" size="100%">Li, Jihua</style></author><author><style face="normal" font="default" size="100%">Reiss, Boris</style></author><author><style face="normal" font="default" size="100%">He, Jun</style></author><author><style face="normal" font="default" size="100%">Tian, Linwei</style></author><author><style face="normal" font="default" size="100%">Yang, Kaiyun</style></author><author><style face="normal" font="default" size="100%">Seow, Wei Jie</style></author><author><style face="normal" font="default" size="100%">Xu, Jun</style></author><author><style face="normal" font="default" size="100%">Kim A Anderson</style></author><author><style face="normal" font="default" size="100%">Ji, Bu-Tian</style></author><author><style face="normal" font="default" size="100%">Silverman, Debra</style></author><author><style face="normal" font="default" size="100%">Chanock, Stephen</style></author><author><style face="normal" font="default" size="100%">Huang, Yunchao</style></author><author><style face="normal" font="default" size="100%">Rothman, Nathaniel</style></author><author><style face="normal" font="default" size="100%">Lan, Qing</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Constituents of Household Air Pollution and Risk of Lung Cancer among Never-Smoking Women in Xuanwei and Fuyuan, China.</style></title><secondary-title><style face="normal" font="default" size="100%">Environ Health Perspect</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Environ. Health Perspect.</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2019 Sep</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">127</style></volume><pages><style face="normal" font="default" size="100%">97001</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;BACKGROUND: &lt;/strong&gt;Lung cancer rates among never-smoking women in Xuanwei and Fuyuan in China are among the highest in the world and have been attributed to the domestic use of smoky (bituminous) coal for heating and cooking. However, the key components of coal that drive lung cancer risk have not been identified.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;OBJECTIVES: &lt;/strong&gt;We aimed to investigate the relationship between lifelong exposure to the constituents of smoky coal (and other fuel types) and lung cancer.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;METHODS: &lt;/strong&gt;Using a population-based case-control study of lung cancer among 1,015 never-smoking female cases and 485 controls, we examined the association between exposure to 43 household air pollutants and lung cancer. Pollutant predictions were derived from a comprehensive exposure assessment study, which included methylated polycyclic aromatic hydrocarbons (PAHs), which have never been directly evaluated in an epidemiological study of any cancer. Hierarchical clustering and penalized regression were applied in order to address high colinearity in exposure variables.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;RESULTS: &lt;/strong&gt;The strongest association with lung cancer was for a cluster of 25 PAHs [odds ratio (OR): 2.21; 95% confidence interval (CI): 1.67, 2.87 per 1 standard deviation (SD) change], within which 5-methylchrysene (5-MC), a mutagenic and carcinogenic PAH, had the highest individual observed OR (5.42; 95% CI: 0.94, 27.5). A positive association with nitrogen dioxide ([Formula: see text]) was also observed (OR: 2.06; 95% CI: 1.19, 3.49). By contrast, neither benzo(a)pyrene (BaP) nor fine particulate matter with aerodynamic diameter [Formula: see text] ([Formula: see text]) were associated with lung cancer in the multipollutant models.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;CONCLUSIONS: &lt;/strong&gt;To our knowledge, this is the first study to comprehensively evaluate the association between lung cancer and household air pollution (HAP) constituents estimated over the entire life course. Given the global ubiquity of coal use domestically for indoor cooking and heating and commercially for electric power generation, our study suggests that more extensive monitoring of coal combustion products, including methylated PAHs, may be warranted to more accurately assess health risks and develop prevention strategies from this exposure. https://doi.org/10.1289/EHP4913.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">9</style></issue></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Quintana, Penelope J E</style></author><author><style face="normal" font="default" size="100%">Hoh, Eunha</style></author><author><style face="normal" font="default" size="100%">Dodder, Nathan G</style></author><author><style face="normal" font="default" size="100%">Matt, Georg E</style></author><author><style face="normal" font="default" size="100%">Zakarian, Joy M</style></author><author><style face="normal" font="default" size="100%">Kim A Anderson</style></author><author><style face="normal" font="default" size="100%">Akins, Brittany</style></author><author><style face="normal" font="default" size="100%">Chu, Linda</style></author><author><style face="normal" font="default" size="100%">Hovell, Melbourne F</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nicotine levels in silicone wristband samplers worn by children exposed to secondhand smoke and electronic cigarette vapor are highly correlated with child&#039;s urinary cotinine.</style></title><secondary-title><style face="normal" font="default" size="100%">J Expo Sci Environ Epidemiol</style></secondary-title><alt-title><style face="normal" font="default" size="100%">J Expo Sci Environ Epidemiol</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2019 Feb 06</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Exposure assessment in children, especially young children, presents difficulties not found with adults. Simple silicone wristbands are passive samplers that have potential applicability in exposure studies of children. We investigated the performance of silicone wristbands as personal nicotine samplers in two wristbands worn by a child (n = 31) for 7 days and for 2 days (worn day 5 to day 7). We compared levels of nicotine in wristbands with urinary cotinine, a metabolite of nicotine, measured in the child&#039;s urine obtained on day 7. Children were recruited who were exposed to contaminants in tobacco smoke and/or vapor from electronic nicotine delivery systems (ENDS; commonly known as electronic cigarettes or EC) as well as children who lived in nonsmoking homes. Caregivers were interviewed to obtain reported measures of the child&#039;s exposure. Analysis was by liquid chromatography with triple quadrupole mass spectrometry and isotope dilution (LC-MS/MS). The nicotine detected in the wristbands worn for 2 days was highly correlated with urinary cotinine concentration (df = 29, r = 0.741, p &amp;lt; 0.001), as was nicotine in wristbands worn for 7 days (df = 28, r = 0.804, p &amp;lt; 0.001). The 2- and 7-day wristband nicotine amounts were also significantly correlated (df = 28, r = 0.852, p &amp;lt; 0.001). Silicone wristbands may be a useful tool for epidemiological and intervention studies of tobacco product exposure in children.&lt;/p&gt;
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