%0 Generic %D 2021 %T Assessing Chemical Movement and Temporality at a Former Creosote Site %A Christine C Ghetu %A D James Minick %A Lane G Tidwell %A Peter D Hoffman %A Kim A Anderson %B SETAC North America 42nd Annual Meeting Portland, OR %8 11/2021 %G eng %0 Generic %D 2021 %T Assessing PAH movement %A Christine C Ghetu %A D James Minick %A Lane G Tidwell %A Peter D Hoffman %A Kim A Anderson %B FSES Data Update with Oregon DEQ, Cascadia, LLC and Port of Columbia, Virtual %8 01/2021 %G eng %0 Generic %D 2020 %T Assessing PAH chemical movement %A Christine C Ghetu %A D James Minick %A Lane G Tidwell %A Peter D Hoffman %A Kim A Anderson %B FSES Data Update with Cascadia, LLC and Port of Columbia, Virtual %8 10/2020 %G eng %0 Audiovisual Material %D 2020 %T Assessing PAH diffusive and advective flux contributions and temporality in the environment %A Christine C Ghetu %A D James Minick %A Lane G Tidwell %A Peter D Hoffman %A Kim A Anderson %B NIEHS Superfund Research Program 2020 Annual Meeting, Virtual %8 12/2020 %G eng %0 Audiovisual Material %D 2019 %T Assessing flux of PAHs across sediment-water and water-air phases at a legacy creosote site in the Pacific Northwest, US. %A Christine C Ghetu %A D James Minick %A Lane G Tidwell %A Peter D Hoffman %A Kim A Anderson %B Environmental Public Health in the 21st Century Research Symposium, Oregon State University Environmental and Molecular Toxicology Research Day, Corvallis, OR %8 01/2019 %G eng %0 Journal Article %J Mar Pollut Bull %D 2019 %T A passive sampling model to predict PAHs in butter clams (Saxidomus giganteus), a traditional food source for Native American tribes of the Salish Sea Region. %A D James Minick %A Paulik, L Blair %A Richard P Scott %A Molly Kile %A Diana Rohlman %A Kim A Anderson %K Animals %K Bivalvia %K Consumer Product Safety %K Environmental Monitoring %K Food Contamination %K Humans %K Indians, North American %K Polycyclic Aromatic Hydrocarbons %K Shellfish %K Water Pollutants, Chemical %X

Native Americans face disproportionate exposures to environmental pollution through traditional subsistence practices including shellfish harvesting. In this study, the collection of butter clams (Saxidomus giganteus) was spatially and temporally paired with deployment of sediment pore water passive samplers at 20 locations in the Puget Sound region of the Salish Sea in the Pacific Northwest, USA, within adjudicated usual and accustomed tribal fishing grounds and stations. Clams and passive samplers were analyzed for 62 individual PAHs. A linear regression model was constructed to predict PAH concentrations in the edible fraction of butter clams from the freely dissolved fraction (C) in porewater. PAH concentrations can be predicted within a factor of 1.9 ± 0.2 on average from the freely dissolved PAH concentration in porewater using the following equation: PAHClam=4.1±0.1×PAHporewater This model offers a simplified, cost effective, and low impact approach to assess contaminant levels in butter clams which are an important traditional food.

%B Mar Pollut Bull %V 145 %P 28-35 %8 2019 Aug %G eng %R 10.1016/j.marpolbul.2019.05.020 %0 Generic %D 2018 %T Assessing flux of PAHs across sediment-water and water-air phases at a legacy creosote site in the Pacific Northwest, US %A Christine C Ghetu %A D James Minick %A Lane G Tidwell %A Peter D Hoffman %A Kim A Anderson %B SETAC North America 39th Annual Meeting, Sacremento, CA %8 11/2018 %G eng %0 Generic %D 2018 %T Assessing flux of PAHs across sediment-water and water-air phases at a legacy creosote site in the Pacific Northwest, US %A Christine C Ghetu %A D James Minick %A Lane G Tidwell %A Kim A Anderson %B 9th Annual Research Day, Department of Environmental and Molecular Toxicology, Corvallis, OR %8 01/2018 %G eng %0 Audiovisual Material %D 2018 %T Assessing flux of PAHs across sediment-water and water-air phases at a legacy creosote site in the Pacific Northwest, US. %A Christine C Ghetu %A D James Minick %A Lane G Tidwell %A Peter D Hoffman %A Kim A Anderson %B NIEHS Superfund Research Program 2018 Annual Meeting, Sacramento, CA. %8 11/2018 %G eng %0 Generic %D 2018 %T Assessing flux of PAHs across sediment-water and water-air phases at a legacy creosote site in St. Helens, Oregon %A Christine C Ghetu %A D James Minick %A Lane G Tidwell %A Kim A Anderson %B 27th PNW-SETAC Annual Conference, Corvallis, OR %8 03/2018 %G eng %0 Generic %D 2018 %T Assessing flux of PAHs across sediment-water and water-air phases at a legacy creosote site in the Pacific Northwest, US %A Christine C Ghetu %A D James Minick %A Lane G Tidwell %A Peter D Hoffman %A Kim A Anderson %B FSES External Advisory Committee Meeting, Yachats, OR %8 10/2018 %G eng %0 Audiovisual Material %D 2018 %T Assessing flux of PAHs across sediment-water and water-air phases at a legacy creosote site in the Pacific Northwest, US %A Christine C Ghetu %A D James Minick %A Lane G Tidwell %A Peter D Hoffman %B 3rd Tribal Environmental Health Summit, Corvallis, OR %8 06/2018 %G eng %0 Journal Article %J Toxicol Appl Pharmacol %D 2018 %T Systematic developmental neurotoxicity assessment of a representative PAH Superfund mixture using zebrafish. %A Mitra Geier %A D James Minick %A Truong, Lisa %A Susan C Tilton %A Pande, Paritosh %A Kim A Anderson %A JG Teeguarden %A Robyn L Tanguay %X

Superfund sites often consist of complex mixtures of polycyclic aromatic hydrocarbons (PAHs). It is widely recognized that PAHs pose risks to human and environmental health, but the risks posed by exposure to PAH mixtures are unclear. We constructed an environmentally relevant PAH mixture with the top 10 most prevalent PAHs (SM10) from a Superfund site derived from environmental passive sampling data. Using the zebrafish model, we measured body burden at 48 hours post fertilization (hpf) and evaluated the developmental and neurotoxicity of SM10 and the 10 individual constituents at 24 hours post fertilization (hpf) and 5 days post fertilization (dpf). Zebrafish embryos were exposed from 6 to 120 hpf to (1) the SM10 mixture, (2) a variety of individual PAHs: pyrene, fluoranthene, retene, benzo[a]anthracene, chrysene, naphthalene, acenaphthene, phenanthrene, fluorene, and 2-methylnaphthalene. We demonstrated that SM10 and only 3 of the individual PAHs were developmentally toxic. Subsequently, we constructed and exposed developing zebrafish to two sub-mixtures: SM3 (comprised of 3 of the developmentally toxicity PAHs) and SM7 (7 non-developmentally toxic PAHs). We found that the SM3 toxicity profile was similar to SM10, and SM7 unexpectedly elicited developmental toxicity unlike that seen with its individual components. The results demonstrated that the overall developmental toxicity in the mixtures could be explained using the general concentration addition model. To determine if exposures activated the AHR pathway, spatial expression of CYP1A was evaluated in the 10 individual PAHs and the 3 mixtures at 5 dpf. Results showed activation of AHR in the liver and vasculature for the mixtures and some individual PAHs. Embryos exposed to SM10 during development and raised in chemical-free water into adulthood exhibited decreased learning and responses to startle stimulus indicating that developmental SM10 exposures affect neurobehavior. Collectively, these results exemplify the utility of zebrafish to investigate the developmental and neurotoxicity of complex mixtures.

%B Toxicol Appl Pharmacol %8 2018 Apr 06 %G eng %R 10.1016/j.taap.2018.03.029 %0 Generic %D 2017 %T 1st Place Student Platform Presentation %A D James Minick %X
%B Pacific Northwest Chapter of the Society of Environmental Toxicology and Chemistry. 26th Annual Meeting %8 04/2017 %G eng %0 Journal Article %J Environ Toxicol Chem %D 2017 %T Diffusive flux of PAHs across sediment-water and water-air interfaces at urban superfund sites. %A D James Minick %A Kim A Anderson %K Air %K Cities %K Geologic Sediments %K Hazardous Waste Sites %K Oregon %K Polycyclic Aromatic Hydrocarbons %K Rivers %K Water %K Water Pollutants, Chemical %X

Superfund sites may be a source of polycyclic aromatic hydrocarbons (PAHs) to the surrounding environment. These sites can also act as PAH sinks from present-day anthropogenic activities, especially in urban locations. Understanding PAH transport across environmental compartments helps to define the relative contributions of these sources and is therefore important for informing remedial and management decisions. In the present study, paired passive samplers were co-deployed at sediment-water and water-air interfaces within the Portland Harbor Superfund Site and the McCormick and Baxter Superfund Site. These sites, located along the Willamette River (Portland, OR, USA), have PAH contamination from both legacy and modern sources. Diffusive flux calculations indicate that the Willamette River acts predominantly as a sink for low molecular weight PAHs from both the sediment and the air. The sediment was also predominantly a source of 4- and 5-ring PAHs to the river, and the river was a source of these same PAHs to the air, indicating that legacy pollution may be contributing to PAH exposure for residents of the Portland urban center. At the remediated McCormick and Baxter Superfund Site, flux measurements highlight locations within the sand and rock sediment cap where contaminant breakthrough is occurring. Environ Toxicol Chem 2017;36:2281-2289. © 2017 SETAC.

%B Environ Toxicol Chem %V 36 %P 2281-2289 %8 2017 09 %G eng %N 9 %R 10.1002/etc.3785 %0 Generic %D 2017 %T Diffusive flux of PAHs across sediment-water and water-air interfaces at urban Superfund sites and economic Implications %A D James Minick %A Kim A Anderson %B American Chemical Socieity National Meeting %8 08/2017 %G eng %0 Audiovisual Material %D 2017 %T Hazard assessment of a PAH Superfund mixture in the zebrafish developmental toxicity model %A D James Minick %A Mitra Geier %A Kim A Anderson %A Robyn L Tanguay %B Society of Toxicology 56th Annual Meeting %C Baltimore %8 03/2017 %G eng %0 Generic %D 2017 %T Hazard assessment of a PAH Superfund mixture in the zebrafish developmental toxicity mode %A D James Minick %A Mitra Geier %A Robyn L Tanguay %A Kim A Anderson %X
%B Pacific Northwest Chapter of the Society of Environmental Toxicology and Chemistry. 26th Annual Meeting %8 04/2017 %G eng %0 Generic %D 2017 %T Pacific Northwest SETAC Travel Award %A D James Minick %X
%8 04/2017 %G eng %0 Generic %D 2017 %T A passive sampling model to predict PAH levels in butter clams, a traditional food source for Native American tribes of the Salish Sea Region %A D James Minick %A Kim A Anderson %B Superfund Program National Meeting %8 12/2017 %G eng %0 Generic %D 2017 %T Team Tox Travel Award %A D James Minick %X
%8 04/2017 %G eng %0 Generic %D 2016 %T Diffusive flux of PAHs across sediment, water, and air interfaces at urban Superfund Sites %A D James Minick %E Kim A Anderson %B SETAC North America 37th Annual Meeting, Orlando, Florida %8 11/2016 %G eng %0 Audiovisual Material %D 2016 %T Diffusive flux of PAHs across sediment, water, and air interfaces at urban Superfund Sites %A D James Minick %E Kim A Anderson %B NIEHS FEST %C Durham, NC %8 12/2016 %G eng %0 Generic %D 2015 %T Assessment of PAH Contribution to Superfund Site Hazard Using a Representative PAH Mixture and a Zebrafish Developmental Toxicity Model %A D James Minick %A Mitra Geier %A Robyn L Tanguay %A Kim A Anderson %B SETAC North America 36th Annual Meeting. Salt Lake City, Utah %8 11/2015 %G eng