Short Description: 

Bio Response Indicator Devices Gauging Environmental Stressors

The BRIDGES (Biological Response Indicator Devices Gauging Environmental Stressors) bioanalytical tool provides a quantitative measure of the toxicity of environmentally relevant contaminant mixtures. It pairs passive sampling with the embryonic zebrafish developmental toxicity model to connect environmental chemical exposures to biological effects. This tool responds to three fundamental needs in toxicology research: 1) determining bioavailability in order to assess potential exposure; 2) evaluating the toxicity of complex mixtures of contaminants in the environment [2]; and 3) directly connecting effective environmental sampling with toxicity evaluations. Furthermore, it allows for the determination of the toxicity of environmentally relevant mixtures, even when all of the components of the mixture are not identified  and can aid in the identification of bioactive chemicals.
The presence of chemicals in the environment is not necessarily indicative of bioavailability; chemicals can only be taken up by organisms and have a biological effect if they are bioavailable. Developing methods for effectively assessing exposure, and integrating these into risk assessment frameworks, has been identified as a priority for ecotoxicology and risk assessment. Although humans and other organisms are exposed to complex mixtures of contaminants, toxicity testing is most often limited to determining the effects of exposure to individual chemicals or classes of chemicals. Developing methods for effectively assessing exposure, and integrating these into risk assessment frameworks, has been identified as a priority for ecotoxicology  and risk assessment. Although humans and other organisms are exposed to complex mixtures of contaminants, toxicity testing is most often limited to determining the effects of exposure to individual chemicals or classes of chemicals. Models for predicting the effects of complex mixtures can be inadequate because they do not account for antagonistic and synergistic interactions between the components of the mixture. Additionally, environmental exposure assessment is carried out by measuring known pollutants in environmental matrices using analytical chemistry. Chemicals that have not been previously identified, such as unknown substances and breakdown products of known contaminants, can escape detection during chemical analysis; however, these unidentified components of the mixture may be toxicologically significant.


Journal Articles

Allan, SE, Smith, BW, Tanguay, RL, Anderson, KA,Bridging environmental mixtures and toxic effects., Environ. Toxicol. Chem. 2012, 31(12), 2877-87

Allan, SE, Sower, GJ, Anderson, KA,Estimating risk at a Superfund site using passive sampling devices as biological surrogates in human health risk models., Chemosphere 2011, 85(6), 920-7

Hillwalker, WE, Allan, SE, Tanguay, RL, Anderson, KA,Exploiting lipid-free tubing passive samplers and embryonic zebrafish to link site specific contaminant mixtures to biological responses., Chemosphere 2010, 79(1), 1-7

Platform/Presentations

Donald, CE, Allan, SE, O'Connell, SG, Smith, BW, Tanguay, RL, Anderson, KA,Component-based analysis of OPAH interaction effects in zebrafish, 2014, SETAC North America 35th Annual Meeting

Bergmann, AJ, Tanguay, RL, Anderson, KA,Teratogenicity of PAHs from Portland Harbor? Effects-directed analysis with passive sampling and developing zebrafish, 2014, OSU SRP Trainee Colloquium

Bergmann, AJ, Tanguay, RL, Anderson, KA,Fractionation of passive sampling device extracts explores contribution of PAHs to zebrafish toxicity, 2013, International Society of Polycyclic Aromatic Compounds

Anderson, KA, Allan, SE, O'Connell, SG, Tidwell, LG,Assessment and source-modeling of bioavailable contaminants in Gulf of Mexico coastal waters before, during and after the Deepwater Horizon oil spill, 2012, 243rd ACS National Meeting

Allan, SE, Smith, BW, Tanguay, RL, Anderson, KA,Bridging Environmental Mixtures and Toxic Effects, 2012, SETAC North America 33rd Annual Meeting

Tidwell, LG, Hobbie, KA, Wilson, GR, O'Connell, SG, Allan, SE, Anderson, KA,Utilizing Passive Sampling for Rapid Response to Assess Atmospheric Exposure to PAHs Before, During and After the Deepwater Horizon Oil Spill., 2012, SETAC North America

Anderson, KA,Biological Response Indicator Devices for Gauging Environmental Stressors (BRIDGES) in the Gulf of Mexico, 2011, Federation of American Societies for Experimental Biology (FASEB) and the Ad Hoc Group for Medical Research, Advancing Discovery: Assessing the Impact of the Gulf Oil Spill

Anderson, KA,Innovative Technologies to Quantify Environmental Contaminant Bioavailability & Exposure, 2011, Invited Seminar Speaker, Special Seminar & Networking Opportunities, Sponsored by the Superfund Research Program, NIEHS In Partnership with NCEH/ATSDR, Centers for Disease Control and Prevention Chamblee Campus

Anderson, KA,Innovative Technologies to Quantify Environmental Contaminant Bioavailability & Exposure, 2011, Invited Workshop Instructor, National Association of Remedial Project Managers, EPA/NIEHS “Passive Sampling Devices Technology”

Anderson, KA,Biological Response Indicator Devices for Gauging Environmental Stressors (BRIDGES), demonstrated the sensitivity of the BRIDGES bio-analytical tool for detecting spatially distinct toxicity in aquatic systems, 2010, Invited Webinar Speaker: NIEHS “Risk eLearning” joint webinar program with EPA. Using Ecological-Based Tools and Approaches to Assess Bioavailability (archived online

Posters

Bergmann, AJ, Donald, CE, Tanguay, R, Anderson, KA,Bridging bioavailable extracts and developing zebrafish to identify toxicants of concern, 2014, Society of Environmental Toxicology and Chemistry North America 34th Annual Meeting, Vancouver, BC, Canada

Bergmann, A, Donald, CE, Tanguay, R, Anderson, KA,Bridging superfund site based bioavailable extracts with biology, 2014, OSU SRP External Advisory Meeting 2014

Donald, CE, O'Connell, SG, Allan, SE, Tanguay, RL, Anderson, KA,Correlating OPAH concentrations with zebrafish toxicity of Deepwater Horizon samples: a bottom-up approach, 2014, EMT Research Day, Corvallis, OR

Donald, CE, O'Connell, SG, Allan, SE, Tanguay, RL, Anderson, KA,Correlating OPAH concentrations with zebrafish toxicity of Deepwater Horizon samples: a bottom-up approach, 2013, SETAC North America National Meeting, Nashville, TN

Donald, CE, O'Connell, SG, Allan, SE, Tanguay, RL, Anderson, KA,Correlating OPAH concentrations with zebrafish toxicity of Gulf of Mexico samples around the Deepwater Horizon oil spill: a bottom-up approach, 2013, International Symposium on Polycyclic Aromatic Hydrocarbons, Corvallis, OR

Bergmann, AJ, Tanguay, RL, Anderson, KA,Fractionation of passive sampling device extracts explores contribution of PAHs to zebrafish toxicity, 2013, SETAC NA, Nashville TN

Allan, SE, Tanguay, RL, Anderson, KA,Developmental toxicity of bioavailable contaminants from the Portland Harbor Superfund site: Bridging environmental mixtures and toxic effects, 2011, SETAC North America 32nd Annual Conference

Corvi, MM, Tanguay, RL, Anderson, KA,An Examination of Pesticide Mixture Toxicity Using Embryonic Zebrafish and Passive Sampling Device Extracts, 2009, FSES Advisory Council

Allan, SE, Hillwalker, WE, Tanguay, RL, Anderson, KA,Environmentally Relevant Assessment Tool: BRIDGING Passive Sampling Devices and the Embryonic Zebrafish Toxicity Model, 2009, FSES Advisory Council

Shorey, L, Hillwalker, WE, Tanguay, RL, Anderson, KA,Health Assessment Approach BRIDGES Environmentally Relevant Contaminant Mixtures and Early Life-Stage Developmental Toxicity, 2008, FSES Advisory Council