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BS Biology, Oregon State University, 1986
BS Microbiology, Oregon State University, 1986
Jun 2016 - Current, Assistant Director, Food Safety and Environmental Stewardship program, Director Dr. Kim A Anderson, Environmental and Molecular Toxicology, Oregon State University.
Jan 2014 - Jun 2016. Senior Faculty Research Assistant. Food Safety and Environmental Stewardship program, Director Dr. Kim A Anderson, Environmental and Molecular Toxicology, Oregon State University
UV-induced degradation of complex Polycylic Aromatic Hydrocarbon (PAH) mixtures under accurately emulated terrestrial conditions.
May 2013 – May 2014 (0.6FTE) Senior Faculty Research Assistant. Laboratory of Dr. Douglas Barofsky, Department of Chemistry/Environmental and Molecular Toxicology, Oregon State University
Responsible for defining the analytical capability of a novel radio frequency-free electromagnetostatic (EMS) cell devised for electron-capture dissociation (ECD) of ions in a electrospray ionization (ESI) hybrid quadrupole/time-of-flight (QTOF) mass spectrometer.
October 2013 – December 2013 (0.4 FTE) Senior Faculty Research Assistant. Laboratory of Dr. Andrew Buermeyer, Department of Environmental and Molecular Toxicology, Oregon State University.
Mismatch repair responses to poly-aromatic hydrocarbon (PAH) treatment of human cell lines. Continuation of an ongoing project defining the spectrum of mutations generated in the human hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene by exposure of mismatch-repair (MMR) proficient and deficient cell lines to PAH/DNA lesion inducing compounds.
1996 – May 2013 Senior Faculty Research Assistant
1990 – 1996 Faculty Research Assistant;
Laboratory of Dr. John Hays, Department of Environmental and Molecular Toxicology, Oregon State University.
Responsible for the management of an active research lab at OSU with a primary focus on DNA repair and genomic stability in a variety of model systems including Arabidopsis thaliana, E. coli, yeast, and cultured human cells.
Donald CE, Elie MR, Smith BW, Hoffman PD, Anderson KA. Transport stability of pesticides and PAHs sequestered in polyethylene passive sampling devices. Environ Sci Pollut Res Int. 2016 Jun;23(12):12392-9. doi: 10.1007/s11356-016-6453-3
Anderson KA, Szelewski MJ, Wilson G, Quimby BD, Hoffman PD. Modified ion source triple quadrupole mass spectrometer gas chromatograph for polycyclic aromatic hydrocarbon analyses. J Chromatogr A. 2015 Nov 6;1419:89-98. doi: 10.1016/j.chroma.2015.09.054.
Voinov VG, Hoffman PD, Bennett SE, Beckman JS, Barofsky DF. Electron Capture Dissociation of Sodium-Adducted Peptides on a Modified Quadrupole/Time-of-Flight Mass Spectrometer. J. Am. Soc. Mass Spectrom. (2015) 26: 2096. doi:10.1007/s13361-015-1230-y
Thurman LL, Garcia TS, Hoffman PD. Elevational differences in trait response to UV-B radiation by long-toed salamander populations. Oecologia. 2014 Jul;175(3):835-45
Bollmann SR, Tominey, CM, Hoffman PD, Hoffman TM, Hays JB. Reversion-reporter transgenes to report all six base-substitution mutations in Arabidopsis. Plant Physiol. 2011 Mar;155(3):1286-300. Epub 2011 Jan 6.
Curtis MJ, Belcram K, Bollmann SR, Tominey CM, Hoffman PD, Mercier R, Hays JB. Reciprocal chromosome translocation associated with TDNA-insertion mutation in Arabidopsis: genetic and cytological analyses of consequences for gametophyte development and for construction of doubly mutant lines. Planta. 2009 Mar;229(4):731-45. Epub 2008 Dec 12.
Hoffman PD, Curtis MJ, Iwai S, Hays JB. Biochemical evolution of DNA polymerase : Properties of plant, human and yeast proteins. Biochemistry. 2008 Apr 22;47(16):4583-96. Epub 2008 Mar 27.
Wang H, Hoffman PD, Lawrence CW, Hays JB. Testing excision models for responses of mismatch-repair systems to UV photoproducts in DNA. Environ Mol Mutagen. 2006 May;47(4):296-306
Hays JB, Hoffman PD, Wang H. Discrimination and versatility in mismatch repair.
DNA Repair (Amst). 2005 Dec 8;4(12):1463-74.
Hoffman PD, Wang H, Lawrence CW, Iwai S, Hanaoka F, Hays JB.
Binding of MutS mismatch repair protein to DNA containing UV photoproducts, "mismatched" opposite Watson--Crick and novel nucleotides, in different DNA sequence contexts. DNA Repair (Amst). 2005 Aug 15;4(9):983-93.
Hoffman PD, Leonard JM, Lindberg GE, Bollmann SR, and Hays JB. Rapid accumulation of mutations during seed-to-seed propagation of mismatch-repair-defective Arabidopsis. Genes Dev. 2004 Nov 1;18(21):2676-85.
Garcia-Ortiz MV, Ariza RR, Hoffman PD, Hays JB, Roldan-Arjona T.
Arabidopsis thaliana AtPOLK encodes a DinB-like DNA polymerase that extends mispaired primer termini and is highly expressed in a variety of tissues.
Plant J. 2004 Jul;39(1):84-97.
Blaustein, A.R., L.K. Belden, A.C. Hatch, L.B. Kats, P.D. Hoffman, J.B. Hays, A. Marco, D.P. Chivers and J. M. Kiesecker. Ultraviolet radiation and amphibians. Pages 63-79. Ecosystems, Evolution, and Ultraviolet Radiation. 2001. C.S. Cockell and A.R. Blaustein, eds. Springer Verlag Publishers, New York.
Hays JB, Hoffman P. Measurement of activities of cyclobutane-pyrimidine-dimer and (6-4)-photoproduct photolyases. Methods Mol Biol. 1999, 113:133-46.
Blaustein, A.R., Hays, JB., Hoffman PD, Chivers DP, Kiesecker JM, Leonard WP, Marco A, Olson, DH., Reaser, JK., and Anthony, RG., DNA repair and resistance to UV-B radiation in western spotted frogs. Ecological Applications. 1999, 9:3:1100-1105.
van de Mortel T, Buttemer W, Hoffman P, Hays J, Blaustein, A. A comparison of photolyase activity in three Australian tree frogs. Oecologia 1998, 115:366-369
Landry LG, Stapleton AE, Lim J, Hoffman P, Hays JB, Walbot V, Last RL.
An Arabidopsis photolyase mutant is hypersensitive to ultraviolet-B radiation. Proc Natl Acad Sci U S A. 1997 Jan 7;94(1):328-32.
Blaustein, A.R., Kiesecker, J.M., Hoffman, P. and J.B. Hayes.. The significance of Ultraviolet-B radiation to amphibian population declines. Reviews in Toxicology: Environmental Toxicology 1997:147-165.
Hoffman PD, Batschauer A, Hays JB. PHH1, a novel gene from Arabidopsis thaliana that encodes a protein similar to plant blue-light photoreceptors and microbial photolyases. Mol Gen Genet. 1996 Nov 27;253(1-2):259-65.
Hays, JB., Blaustein, AR., Kiesecker, JM., Hoffman, PD., Pandelova, I. Responses of amphibians to solar and artificial UV light: photorepair, survival, and developmental effects. Proceedings International Congress of Photobiology, Vienna, Austria, Sept 1996.
Hays, JB, Blaustein AR, Kiesecker JM, Hoffman PD, Pandelova I, Coyle D, Richardson T. Developmental responses of amphibians to solar and artificial UVB sources: a comparative study. Photochem Photobiol. 1996 Sep;64(3):449-56.
Blaustein, A.R., Hoffman, P.D., Kiesecker, J.M. and J.B. Hays. DNA repair activity and resistance to solar UV-B radiation in eggs of the red-legged frog: Implications for population declines. Conservation Biology, 1996. 10:1398-1402.
Hays, J., Hoffman, P.D., Blaustein, A.R., Differences in DNA-repair activity and sensitivity to UV-B light among eggs and oocytes of declining and stable amphibian species. Journal of Cellular Biochemistry, 1995. 296
Blaustein AR, Hoffman PD, Hokit DG, Kiesecker JM, Walls SC, Hays JB. UV repair and resistance to solar UV-B in amphibian eggs: a link to population declines? Proc Natl Acad Sci U S A. 1994 Mar 1;91(5):1791-5.