%0 Journal Article %J Toxics %D 2022 %T Leveraging Multiple Data Streams for Prioritization of Mixtures for Hazard Characterization. %A Rivera, Brianna N %A Christine C Ghetu %A Yvonne Chang %A Truong, Lisa %A Robyn L Tanguay %A Kim A Anderson %X

There is a growing need to establish alternative approaches for mixture safety assessment of polycyclic aromatic hydrocarbons (PAHs). Due to limitations with current component-based approaches, and the lack of established methods for using whole mixtures, a promising alternative is to use sufficiently similar mixtures; although, an established framework is lacking. In this study, several approaches are explored to form sufficiently similar mixtures. Multiple data streams including environmental concentrations and empirically and predicted toxicity data for cancer and non-cancer endpoints were used to prioritize chemical components for mixture formations. Air samplers were analyzed for unsubstituted and alkylated PAHs. A synthetic mixture of identified PAHs was created (Creosote-Fire Mix). Existing toxicity values and chemical concentrations were incorporated to identify hazardous components in the Creosote-Fire Mix. Sufficiently similar mixtures of the Creosote-Fire Mix were formed based on (1) relative abundance; (2) toxicity values; and (3) a combination approach incorporating toxicity and abundance. Hazard characterization of these mixtures was performed using high-throughput screening in primary normal human bronchial epithelium (NHBE) and zebrafish. Differences in chemical composition and potency were observed between mixture formation approaches. The toxicity-based approach (Tox Mix) was the most potent mixture in both models. The combination approach (Weighted-Tox Mix) was determined to be the ideal approach due its ability to prioritize chemicals with high exposure and hazard potential.

%B Toxics %V 10 %8 2022 Oct 29 %G eng %N 11 %R 10.3390/toxics10110651 %0 Generic %D 2017 %T Leveraging passive sampling and unique equine population exposures to assess negative post-natal health outcomes %A Lane G Tidwell %E Carey E Donald %E Kathleen Mullen %E Kim A Anderson %X

In 2012 a high prevalence of neonatal foals born with neurological deficits (altered mentation and dysphagia) was observed at a farm located in Pennsylvania (PA) near a number of unconventional natural gas drilling (UNGD) sites.  The farm proprietor also owned another horse farm in New York (NY) that was not situated near UNGD sites. Newborn foals and mares on the NY farm did not exhibit similar health issues. Over the last 5 years the frequency of dysphagia in foals at the PA facility has increased from 25 to 92%.  From 2014 to 2016 passive sampling devices (PSDs) were deployed on brood mares at both farms continually, and PSDs were changed out every six weeks. PSDs were also deployed in the ambient air and in well water at each farm. . 

%B International Society of Exposure Science %8 10/2017 %G eng %0 Journal Article %J Digital System Design (DSD), 2015 Euromicro Conference on %D 2015 %T Linking the Physical with the Perceptual: Health and Exposure Monitoring with Cyber-physical Questionnaires %A Scaffidi, Chris %A Laurel D Kincl %A Diana Rohlman %A Kim A Anderson %B Digital System Design (DSD), 2015 Euromicro Conference on %P 563-566 %8 08/2015 %G eng %R 10.1109 %0 Audiovisual Material %D 2012 %T Legacy pollutant levels in crayfish compared to passive sampling devices: Determination of correlations and development of bioaccumulation models %A Norman D Forsberg %A Gregory J Sower %A Brian W Smith %A Kim A Anderson %X

Polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) are persistent organic compounds that continue to drive risk management efforts. In order to characterize exposure pathways and assess human health risks associated with consumption of contaminated resident fish, regulatory agencies conventionally analyze homogenized fish tissue samples for PAHs and PCBs. However, obtaining fish for analysis is challenging, the analysis is destructive, and the analysis offers limited spatial and temporal information due in part to biological and physiological variability. For these reasons, an alternative tool capable of accurately predicting fish tissue contaminant levels would be useful to regulatory agencies and risk managers.

Passive sampling devices (PSDs) sample the bioavailable fraction of chemicals, are readily available in large numbers, provide a non-destructive sampling method, yield simpler chemicals analyses, and are capable of identifying spatial and temporal contamination patterns. We hypothesize that PSDs are capable of providing site-independent predictions of chemical load in aquatic tissues with useful accuracy. To test this, PSDs were deployed in the water column at 8 different sites within and outside of the Portland Harbor Superfund Megasite for 24 days. Simultaneously, nearly 100 resident crayfish were collected. Sites selected for PSD and crayfish sampling represented a wide range of PAH and PCB concentrations. PSDs and crayfish were then analyzed for 16 priority pollutant PAHs and 32 dioxin and non-dioxin like PCB congeners using a novel analytical method. Presented results will include regression analyses on total contaminant loads (ΣPAH + PCBs), chemical class specific loads (ΣPAHs, ΣPCBs), and individual contaminant of concern loads. Additionally, we will determine PSD-crayfish specific bioaccumulation factors (BAFPSD-CF) for a wide suite of contaminants of concern. PAH and PCB PSD loads will subsequently be used as surrogates for crayfish and used to generate human health risk estimates. Estimates will then be compared to risk results reported in the Portland Harbor Public health assessment for consumption of impacted resident crayfish. Results from this study will help identify novel PSD applications that could provide useful information to regulators and risk managers.

%B SETAC North American 33rd Annual National Conference %8 11/2012 %G eng