%0 Journal Article %D 2023 %T Follicular DNA Damage and Pesticide Exposure Among Latinx Children in Rural and Urban Communities %A Cassandra Lepetit %A Mohamed Gaber %A Ke Zhou %A Haiying Chen %A Julia Holmes %A Phillip Summers %A Kim A Anderson %A Richard P Scott %A Carey N Pope %A Kirstin Hester %A Paul J Laurienti %A Sara A Quandt %A Thomas A Arcury %A Pierre‑Alexandre Vidi %X

The intersectional risks of children in United States immigrant communities include environmental exposures. Pesticide exposures and their biological outcomes are not well characterized in this population group. We assessed pesticide exposure and related these exposures to DNA double-strand breaks (DSBs) in Latinx children from rural, farmworker families (FW; N = 30) and from urban, non-farmworker families (NFW; N = 15) living in North Carolina. DSBs were quantified in hair follicular cells by immunostaining of 53BP1, and exposure to 72 pesticides and pesticide degradation products were determined using silicone wristbands. Cholinesterase activity was measured in blood samples. DSB frequencies were higher in FW compared to NFW children. Seasonal effects were detected in the FW group, with highest DNA damage levels in April–June and lowest levels in October–November. Acetylcholinesterase depression had the same seasonality and correlated with follicular DNA damage. Organophosphate pesticides were more frequently detected in FW than in NFW children. Participants with organophosphate detections had increased follicular DNA damage compared to participants without organophosphate detection. Follicular DNA damage did not correlate with organochlorine or pyrethroid detections and was not associated with the total number of pesticides detected in the wristbands. These results point to rural disparities in pesticide exposures and their outcomes in children from vulnerable immigrant communities. They suggest that among the different classes of pesticides, organophosphates have the strongest genotoxic effects. Assessing pesticide exposures and their consequences at the individual level is key to environmental surveillance programs. To this end, the minimally invasive combined approach used here is particularly well suited for children.

%8 09/2023 %G eng %0 Generic %D 2022 %T Firefighter Dermal Exposure Assessment with Silicone Samplers %A Emily M Bonner %A Gavin P Horn %A Denise L Smith %A Steven Kerber %A Kenneth W Fent %A Richard P Scott %A Lane G Tidwell %A Kim A Anderson %B SOT San Diego %8 03/2022 %G eng %0 Generic %D 2022 %T Firefighter Dermal Exposure to PAHs Assessed with Silicone Samplers %A Emily M Bonner %A Gavin P Horn %A Denise L Smith %A Steven Kerber %A Kenneth W Fent %A Lane G Tidwell %A Richard P Scott %A Kaley A Adams %A Kim A Anderson %B 43rd SETAC North America %C Pittsburg, PA %8 11/2022 %G eng %0 Generic %D 2021 %T Fall 2021 Dissertation Completion Award %A Christine C Ghetu %B Oregon State University Graduate School %8 09/2021 %G eng %0 Journal Article %J Environ Int %D 2021 %T Firefighter exposures to potential endocrine disrupting chemicals measured by military-style silicone dog tags. %A Carolyn M Poutasse %A Christopher K Haddock %A Walker S Carlos Poston %A Sara A Jahnke %A Lane G Tidwell %A Emily M Bonner %A Peter D Hoffman %A Kim A Anderson %X

Studies suggest that exposure to potential endocrine disrupting chemicals (pEDCs) may contribute to adverse health outcomes, but pEDC exposures among firefighters have not been fully characterized. Previously, we demonstrated the military-style silicone dog tag as a personal passive sampling device for assessing polycyclic aromatic hydrocarbon exposures among structural firefighters. This follow-up analysis examined the pEDC exposures based on department call volume, duty shift, and questionnaire variables. Structural firefighters (n = 56) were from one high and one low fire call volume department (Kansas City, MO metropolitan area) and wore separate dog tags while on- and off-duty (n = 110). The targeted 1530 analyte semi-quantitative screening method was conducted using gas chromatography mass spectrometry (n = 433). A total of 47 pEDCs were detected, and several less-frequently-detected pEDCs (<75%) were more commonly detected in off- compared to on-duty dog tags (conditional logistic regression). Of the 11 phthalates and fragrances detected most frequently (>75%), off-duty pEDC concentrations were strongly correlated (r = 0.31-0.82, p < 0.05), suggesting co-applications of phthalates and fragrances in consumer products. Questionnaire variables of "regular use of conventional cleaning products" and "fireplace in the home" were associated with select elevated pEDC concentrations by duty shift (paired t-test). This suggested researchers should include detailed questions about consumer product use and home environment when examining personal pEDC exposures.

%B Environ Int %V 158 %P 106914 %8 2021 Oct 11 %G eng %R 10.1016/j.envint.2021.106914 %0 Generic %D 2018 %T Feline Hyperthyroidism and Household Chemical Exposures %A Carolyn M Poutasse %A Kim A Anderson %B 9th Annual Research Day, Department of Environmental and Molecular Toxicology, Corvallis, OR %8 01/2018 %G eng %0 Audiovisual Material %D 2014 %T Fractionation of passive sampling device extracts explores contribution of PAHs to zebrafish toxicity %A Alan J Bergmann %A Robyn L Tanguay %A Kim A Anderson %B EMT 2014 Research Day %8 01/2014 %G eng %0 Generic %D 2013 %T Fractionation of passive sampling device extracts explores contribution of PAHs to zebrafish toxicity %A Alan J Bergmann %A Robyn L Tanguay %A Kim A Anderson %B International Society of Polycyclic Aromatic Compounds %8 09/2013 %G eng %0 Audiovisual Material %D 2013 %T Fractionation of passive sampling device extracts explores contribution of PAHs to zebrafish toxicity %A Alan J Bergmann %A Robyn L Tanguay %A Kim A Anderson %B SETAC NA, Nashville TN %8 11/2013 %G eng %0 Audiovisual Material %D 2013 %T Fractionation of passive sampling device extracts explores contribution of PAHs to zebrafish toxicity %A Alan J Bergmann %A Kim A Anderson %B FSES External Advisory Meeting %8 06/2013 %G eng %0 Generic %D 2012 %T Ford Family Scholarship %A Wold, Rachel %B The Ford Family Foundation %8 01/2012 %G eng %0 Journal Article %J Environ Sci Technol %D 2008 %T Field trial and modeling of uptake rates of in situ lipid-free polyethylene membrane passive sampler. %A Kim A Anderson %A D Sethajintanin %A Gregory J Sower %A Quarles, L %K Lipids %K Membranes, Artificial %K Models, Molecular %K Models, Theoretical %K Polyethylene %K Quality Control %X

Lipid-free polyethylene membrane tubing (LFT) has been further developed in response to a growing need for an inexpensive and simple time-integrative sampling device for dissolved hydrophobic contaminants in water. The LFT sampler is based on the diffusion of dissolved hydrophobic target compounds through the aqueous boundary layer and into the polyethylene membrane, mimicking uptake by organisms. We demonstrate through laboratory and field validation studies that LFT provided the same benefits as many other passive sampling devices, withoutthe potential of analytical interference from lipid impurities. A total of 370 LFTs and semipermeable membrane devices were deployed for 21 days in paired studies at highly urbanized, undeveloped, and two Superfund sites, representing several river conditions. A simple internal surrogate spiking method served as an in situ calibration indicator of the effects of environmental conditions on the uptake rates. A modified extraction method for the LFT increased recoveries while decreasing solvent use and labor compared to other organic extraction procedures. LFT sampling rates were estimated using ratios, in situ calibration and modeling for over 45 target analytes, including PAHs, PCBs, and pesticides.

%B Environ Sci Technol %V 42 %P 4486-93 %8 06/2008 %G eng %N 12 %1 http://www.ncbi.nlm.nih.gov/pubmed/18605575?dopt=Abstract %0 Journal Article %J Science %D 1998 %T Fingerprinting the Potato %A Brian W Smith %A Kim A Anderson %B Science %V 281 %8 07/1998 %G eng %& 511 %0 Journal Article %J Lipids %D 1983 %T Fatty acid composition of liver lipids in rats fed brominated fatty acids. %A Tinsley, I J %A Lowry, R R %K Bromine %K Dietary Fats %K Fatty Acids %K Lipid Metabolism %K Liver %X

Feeding rats diets containing brominated corn oil or di- or tetrabromostearate as the monoglyceride produced changes in fatty acid composition of liver lipids. Those changes associated with the feeding of brominated corn oil or tetrabromostearate could be explained by the accumulation of triglyceride, and the changes associated with the feeding of dibromostearate could result from the proliferation of a membrane system. A unique response to the feeding of diets containing brominated corn oil is an increase in the level of gamma-linolenic acid.

%B Lipids %V 18 %P 661-3 %8 1983 Sep %G eng %N 9 %R 10.1007/BF02534679