%0 Journal Article %D 2023 %T Data to Accompany: Expanding the access of wearable silicone wristbands in community-engaged research through best practices in data analysis and integration %A Lisa M Bramer %A Holly Dixon %A Degnan, David J %A Diana Rohlman %A Julie Herbstman %A Kim A Anderson %A Katrina M Waters %X

Wearable silicone wristbands are a rapidly growing exposure assessment technology that offer researchers the ability to study previously inaccessible cohorts and have the potential to provide a more comprehensive picture of chemical exposure within diverse communities. However, there are no established best practices for analyzing the data within a study or across multiple studies, thereby limiting impact and access of these data for larger meta-analyses. We utilize data from three studies, from over 600 wristbands worn by participants in New York City and Eugene, Oregon, to present a first-of-its-kind manuscript detailing wristband data properties. We further discuss and provide concrete examples of key areas and considerations in common statistical modeling methods where best practices must be established to enable meta-analyses and integration of data from multiple studies. Finally, we detail important and challenging aspects of machine learning, meta-analysis, and data integration that researchers will face in order to extend beyond the limited scope of individual studies focused on specific populations.

%8 09/2023 %G eng %0 Journal Article %J Environ Res %D 2023 %T Determinants of exposure to endocrine disruptors following hurricane Harvey. %A Samantha Samon %A Diana Rohlman %A Lane G Tidwell %A Peter D Hoffman %A Abiodun O Oluyomi %A Walker, C %A Melissa Bondy %A Kim A Anderson %X

Hurricane Harvey was a category four storm that induced catastrophic flooding in the Houston metropolitan area. Following the hurricane there was increased concern regarding chemical exposures due to damage caused by flood waters and emergency excess emissions from industrial facilities. This study utilized personal passive samplers in the form of silicone wristbands in Houston, TX to both assess chemical exposure to endocrine disrupting chemicals (EDCs) immediately after the hurricane and determine participant characteristics associated with higher concentrations of exposure. Participants from the Houston-3H cohort (n = 172) wore a wristband for seven days and completed a questionnaire to determine various flood-related and demographic variables. Bivariate and multivariate analysis indicated that living in an area with a high Area Deprivation Index (ADI) (indicative of low socioeconomic status), identifying as Black/African American or Latino, and living in the Houston neighborhoods of Baytown and East Houston were associated with increased exposure to EDCs. These results provide evidence of racial/ethnic and socioeconomic injustices in exposure to EDCs in the Houston Metropolitan Area. Since the multiple regression models conducted did not fully explain exposure (0.047 < R2 < 0.34), more research is needed on the direct sources of EDCs within this area to create effective exposure mitigation strategies.

%B Environ Res %P 114867 %8 01/2023 %G eng %R 10.1016/j.envres.2022.114867 %0 Journal Article %J Sci Total Environ %D 2023 %T Diffusive fluxes of persistent organic pollutants between Arctic atmosphere, surface waters and sediments. %A Ian L Moran %A Lane G Tidwell %A Michael L Barton %A Molly Kile %A Miller, Pamela %A Diana Rohlman %A Seguinot-Medina, Samarys %A Ungwiluk, Bobby %A Waghiyi, Vi %A Kim A Anderson %X

Arctic communities are disproportionately exposed to pollutants from sources including global atmospheric transport and formerly used defense sites (FUDS). The effects of climate change and increasing development in the Arctic have the potential to exacerbate this problem. Yupik People of Sivuqaq, or St Lawrence Island, Alaska are one such community with documented exposures to pollutants from FUDS, and their traditional lipid-rich foods such as blubber and rendered oils of marine mammals. Troutman Lake, adjacent to the Yupik community of Gambell, Alaska, was used as a disposal site during the decommission of the adjacent FUDS, leading to community concern about exposure to military pollution and intrusion from historic local dump sites. In collaboration with a local community group, this study utilized passive sampling devices deployed in Troutman Lake. Air, water and sediment deployed samplers were analyzed for unsubstituted and alkylated polycyclic aromatic hydrocarbons (PAHs), brominated and organophosphate flame retardants and polychlorinated biphenyls (PCBs). PAH concentrations were low and comparable to other remote/rural locations. PAHs were generally in deposition from the overlying atmosphere into Troutman Lake. Of the flame retardants, brominated diphenyl ether-47 was detected in all surface water samplers while triphenyl phosphate was detected in all environmental compartments. Both were at concentrations equivalent or lower than other remote locations. Of particular interest, we measured higher atmospheric concentrations of tris(2-chloroethyl) phosphate (TCEP) (0.75-2.8 ng/m) than previously reported in the literature for remote Arctic sites (<0.017-0.56 ng/m). TCEP was found to be in deposition to Troutman Lake at magnitudes from 290 to 1300 ng/m/day. No PCBs were detected in this study. Our findings demonstrate the relevance of both modern and legacy chemicals from local and global sources. These results help us to understand the fate of anthropogenic contaminants in dynamic Arctic systems providing valuable data for communities, policy makers and scientists.

%B Sci Total Environ %P 164566 %8 2023 Jun 01 %G eng %R 10.1016/j.scitotenv.2023.164566 %0 Journal Article %J Citiz Sci %D 2022 %T Designing Equitable, Transparent Community-Engaged Disaster Research. %A Diana Rohlman %A Samantha Samon %A Sarah E Allan %A Michael L Barton %A Holly Dixon %A Christine C Ghetu %A Lane G Tidwell %A Peter D Hoffman %A Abiodun O Oluyomi %A Symanski, Elaine %A Melissa Bondy %A Kim A Anderson %X

Disaster research faces significant infrastructure challenges: regional and federal coordination, access to resources, and community collaboration. Disasters can lead to chemical exposures that potentially impact human health and cause concern in affected communities. Community-engaged research, which incorporates local knowledge and voices, is well-suited for work with communities that experience impacts of environmental exposures following disasters. We present three examples of community-engaged disaster research (CEnDR) following oil spills, hurricanes, and wildfires, and their impact on long-term social, physical, and technical community infrastructure. We highlight the following CEnDR structures: researcher/community networks; convenient research tools; adaptable data collection modalities for equitable access; and return of data.

%B Citiz Sci %V 7 %8 2022 %G eng %N 1 %R 10.5334/cstp.443 %0 Journal Article %J J Expo Sci Environ Epidemiol %D 2022 %T Determining chemical air equivalency using silicone personal monitors. %A Steven G O'Connell %A Kim A Anderson %A Epstein, Marc I %K Air Pollutants %K Environmental Monitoring %K Humans %K Silicones %K Volatile Organic Compounds %X

BACKGROUND: Silicone personal samplers are increasingly being used to measure chemical exposures, but many of these studies do not attempt to calculate environmental concentrations.

OBJECTIVE: Using measurements of silicone wristband uptake of organic chemicals from atmospheric exposure, create log K and k predictive models based on empirical data to help develop air equivalency calculations for both volatile and semi-volatile organic compounds.

METHODS: An atmospheric vapor generator and a custom exposure chamber were used to measure the uptake of organic chemicals into silicone wristbands under simulated indoor conditions. Log K models were evaluated using repeated k-fold cross-validation. Air equivalency was compared between best-performing models.

RESULTS: Log K and log k estimates calculated from uptake data were used to build predictive models from boiling point (BP) and other parameters (all models: R = 0.70-0.94). The log K models were combined with published data and refined to create comprehensive and effective predictive models (R: 0.95-0.97). Final estimates of air equivalency using novel BP models correlated well over an example dataset (Spearman r = 0.984) across 5-orders of magnitude (<0.05 to >5000 ng/L).

SIGNIFICANCE: Data from silicone samplers can be translated into air equivalent concentrations that better characterize environmental concentrations associated with personal exposures and allow direct comparisons to regulatory levels.

%B J Expo Sci Environ Epidemiol %V 32 %P 268-279 %8 2022 03 %G eng %N 2 %R 10.1038/s41370-021-00332-6 %0 Conference Paper %B International Society of Exposure Science 31st Annual Meeting %D 2021 %T Determinants of Exposure to Endocrine Disrupting Chemicals Following Hurricane Harvey %A Samantha Samon %A Diana Rohlman %A Lane G Tidwell %A Peter D Hoffman %A Abiodun O Oluyomi %A Cheryl Walker %A Winnifred Hamilton %A Armstrong, Georgina %A Melissa Bondy %A Kim A Anderson %B International Society of Exposure Science 31st Annual Meeting %C Virtual, Oral Presentation %G eng %0 Conference Paper %B SETAC North America 42nd Annual Meeting %D 2021 %T Determinants of Exposure to Endocrine Disrupting Chemicals Following Hurricane Harvey %A Samantha Samon %A Diana Rohlman %A Lane G Tidwell %A Peter D Hoffman %A Abiodun O Oluyomi %A Cheryl Walker %A Winnifred Hamilton %A Armstrong, Georgina %A Melissa Bondy %A Kim A Anderson %B SETAC North America 42nd Annual Meeting %C Virtual, Poster %G eng %0 Conference Paper %B Society of Toxicology 60th Annual Meeting %D 2021 %T Determinants of exposure to potential endocrine disrupting chemicals following Hurricane Harvey %A Samantha Samon %A Diana Rohlman %A Lane G Tidwell %A Peter D Hoffman %A Abiodun O Oluyomi %A Cheryl Walker %A Winnifred Hamilton %A Armstrong, Georgina %A Melissa Bondy %A Kim A Anderson %B Society of Toxicology 60th Annual Meeting %C Virtual, Poster %G eng %0 Generic %D 2020 %T Discovery of Firefighter Chemical Exposures Using Military-Style Silicone Dog Tags %A Carolyn M Poutasse %A Sara A Jahnke %A Walker S Carlos Poston %A Christopher K Haddock %A Lane G Tidwell %A Peter D Hoffman %A Kim A Anderson %B 10th Annual OSU EMT Research Day, Corvallis, OR %8 1/2020 %G eng %0 Journal Article %J Environ Int %D 2020 %T Discovery of firefighter chemical exposures using military-style silicone dog tags. %A Carolyn M Poutasse %A Walker S Carlos Poston %A Sara A Jahnke %A Christopher K Haddock %A Lane G Tidwell %A Peter D Hoffman %A Kim A Anderson %X

Occupational chemical hazards in the fire service are hypothesized to play a role in increased cancer risk, and reliable sampling technologies are necessary for conducting firefighter chemical exposure assessments. This study presents the military-style dog tag as a new configuration of silicone passive sampling device to sample individual firefighters' exposures at one high and one low fire call volume department in the Kansas City, Missouri metropolitan area. The recruited firefighters (n = 56) wore separate dog tags to assess on- and off-duty exposures (n = 110), for a total of 30 24 h shifts. Using a 63 PAH method (GC-MS/MS), the tags detected 45 unique PAHs, of which 18 have not been previously reported as firefighting exposures. PAH concentrations were higher for on- compared to off-duty tags (0.25 < Cohen's d ≤ 0.80) and for the high compared to the low fire call volume department (0.25 ≤ d < 0.70). Using a 1530 analyte screening method (GC-MS), di-n-butyl phthalate, diisobutyl phthalate, guaiacol, and DEET were commonly detected analytes. The number of fire attacks a firefighter participated in was more strongly correlated with PAH concentrations than firefighter rank or years in the fire service. This suggested that quantitative data should be employed for firefighter exposure assessments, rather than surrogate measures. Because several detected analytes are listed as possible carcinogens, future firefighter exposure studies should consider evaluating complex mixtures to assess individual health risks.

%B Environ Int %V 142 %P 105818 %8 2020 Jun 07 %G eng %R 10.1016/j.envint.2020.105818 %0 Journal Article %J Sci Total Environ %D 2019 %T Determinants of pesticide concentrations in silicone wristbands worn by Latina adolescent girls in a California farmworker community: The COSECHA youth participatory action study. %A Harley, Kim G %A Parra, Kimberly L %A Jose Camacho %A Asa Bradman %A Nolan, James E S %A Lessard, Chloe %A Kim A Anderson %A Carolyn M Poutasse %A Richard P Scott %A Lazaro, Giselle %A Edgar Cardoso %A Daisy Gallardo %A Gunier, Robert B %X

Personal exposure to pesticides has not been well characterized, especially among adolescents. We used silicone wristbands to assess pesticide exposure in 14 to 16 year old Latina girls (N = 97) living in the agricultural Salinas Valley, California, USA and enrolled in the COSECHA (CHAMACOS of Salinas Examining Chemicals in Homes and Agriculture) Study, a youth participatory action study in an agricultural region of California. We determined pesticide concentrations (ng/g/day) in silicone wristbands worn for one week using gas chromatography electron capture detection and employed gas chromatography mass spectrometry to determine the presence or absence of over 1500 chemicals. Predictors of pesticide detections and concentrations were identified using logistic regression, Wilcoxon rank sum tests, and Tobit regression models. The most frequently detected pesticides in wristbands were fipronil sulfide (87%), cypermethrin (56%), dichlorodiphenyldichloroethylene (DDE) (56%), dacthal (53%), and trans-permethrin (52%). Living within 100 m of active agricultural fields, having carpeting in the home, and having an exterminator treat the home in the past six months were associated with higher odds of detecting certain pesticides. Permethrin concentrations were lower for participants who cleaned their homes daily (GM: 1.9 vs. 6.8 ng/g/day, p = 0.01). In multivariable regression models, participants with doormats in the entryway of their home had lower concentrations (p < 0.05) of cypermethrin (87%), permethrin (99%), fipronil sulfide (69%) and DDE (75%). The results suggest that both nearby agricultural pesticide use and individual behaviors are associated with pesticide exposures.

%B Sci Total Environ %V 652 %P 1022-1029 %8 2018 Oct 23 %G eng %R 10.1016/j.scitotenv.2018.10.276 %0 Audiovisual Material %D 2019 %T Determining Environmental Exposure Profiles of Health and Dysphagic Foals %A Briana N Rivera %A Kathleen Mullen %A Lane G Tidwell %A Renata Ivanek %A Dorothy Ainsworth %A Susan C Tilton %A Kim A Anderson %B Society of Environmental Toxicology and Chemistry North America, Toronto, ON %8 11/2019 %G eng %0 Audiovisual Material %D 2019 %T Determining Environmental Exposure Profiles of Health and Dysphagic Foals %A Briana N Rivera %A Kathleen Mullen %A Lane G Tidwell %A Renata Ivanek %A Dorothy Ainsworth %A Susan C Tilton %A Kim A Anderson %B Superfund Research Program, Seattle, WA %8 11/2019 %G eng %0 Journal Article %J BMC Public Health %D 2019 %T Development of an environmental health tool linking chemical exposures, physical location and lung function. %A Diana Rohlman %A Holly Dixon %A Laurel D Kincl %A Larkin, Andrew %A Evoy, Richard %A Michael L Barton %A Phillips, Aaron %A Elena S Peterson %A Scaffidi, Christopher %A Julie Herbstman %A Katrina M Waters %A Kim A Anderson %X

BACKGROUND: A challenge in environmental health research is collecting robust data sets to facilitate comparisons between personal chemical exposures, the environment and health outcomes. To address this challenge, the Exposure, Location and lung Function (ELF) tool was designed in collaboration with communities that share environmental health concerns. These concerns centered on respiratory health and ambient air quality. The ELF collects exposure to polycyclic aromatic hydrocarbons (PAHs), given their association with diminished lung function. Here, we describe the ELF as a novel environmental health assessment tool.

METHODS: The ELF tool collects chemical exposure for 62 PAHs using passive sampling silicone wristbands, geospatial location data and respiratory lung function measures using a paired hand-held spirometer. The ELF was tested by 10 individuals with mild to moderate asthma for 7 days. Participants wore a wristband each day to collect PAH exposure, carried a cell phone, and performed spirometry daily to collect respiratory health measures. Location data was gathered using the geospatial positioning system technology in an Android cell-phone.

RESULTS: We detected and quantified 31 PAHs across the study population. PAH exposure data showed spatial and temporal sensitivity within and between participants. Location data was used with existing datasets such as the Toxics Release Inventory and the National Oceanic and Atmospheric Administration (NOAA) Hazard Mapping System. Respiratory health outcomes were validated using criteria from the American Thoracic Society with 94% of participant data meeting standards. Finally, the ELF was used with a high degree of compliance (> 90%) by community members.

CONCLUSIONS: The ELF is a novel environmental health assessment tool that allows for personal data collection spanning chemical exposures, location and lung function measures as well as self-reported information.

%B BMC Public Health %V 19 %P 854 %8 2019 Jul 01 %G eng %N 1 %R 10.1186/s12889-019-7217-z %0 Journal Article %J Chemosphere %D 2019 %T Differential exposure to organophosphate flame retardants in mother-child pairs. %A Gibson, Elizabeth A %A Heather M Stapleton %A Lehyla Calero %A Darrell Holmes %A Burke, Kimberly %A Martinez, Rodney %A Cortes, Boris %A Nematollahi, Amy %A Evans, David %A Kim A Anderson %A Julie Herbstman %K Adult %K Child %K Child Development %K Child, Preschool %K Cohort Studies %K Dust %K Environmental Exposure %K Female %K Flame Retardants %K Humans %K Male %K Mothers %K Organophosphates %K Young Adult %X

BACKGROUND: Humans are ubiquitously exposed to flame retardants, including organophosphate esters (OPEs), through direct contact with consumer products or exposure through household dust. Children are at increased risk because of their proximity to dust, hand-to-mouth activity, and the importance of childhood as a critical period in neurodevelopment.

OBJECTIVES: To quantify differences in exposure levels between mothers and children (three to six years of age), we analyzed urinary metabolites of OPEs. We additionally assessed the ability of silicone wristbands (measuring ambient exposure) to predict urinary metabolite concentrations.

METHODS: We selected 32 mother and child dyads from an existing cohort. Participants provided baseline urine samples and wore wristbands for one week. After the first week, they returned their wristbands and provided a second urine sample. During the second week, participants wore a second wristband that they returned at the end of week two with a third and final urine sample.

RESULTS: We found significantly higher levels of bis(1,3-dichloro-2-propyl) phosphate (BDCIPP) (p < 0.001) and lower levels of bis(1-chloro-2-isopropyl) 1-hydroxy-2-propyl phosphate (BCIPHIPP) (p < 0.001) in children's urine samples compared to mothers' samples at baseline. We found that triphenylphosphate (TPHP), tris(1,3-dichloroisopropyl) phosphate (TDCIPP), and tris(1-chloro-2-propyl) phosphate (TCIPP) measured in wristbands predicted their respective metabolite levels in urine.

CONCLUSION: Children had higher levels than mothers for two of six flame retardant metabolites measured in urine. Generally, wristband measurements positively predicted internal dose. As little is known about the health effects of OPEs on child development, future research is needed to determine the impact of differential exposure.

%B Chemosphere %V 219 %P 567-573 %8 2019 Mar %G eng %R 10.1016/j.chemosphere.2018.12.008 %0 Audiovisual Material %D 2019 %T Discovery of common chemical exposures across three continents using silicone wristbands %A Holly Dixon %A Armstrong, Georgina %A Michael L Barton %A Alan J Bergmann %A Melissa Bondy %A Mary L Halbleib %A Erin N Haynes %A Julie Herbstman %A Winnifred Hamilton %A Peter D Hoffman %A Paul C Jepson %A Molly Kile %A Laurel D Kincl %A Paul J Laurienti %A Paula E North %A LB Paulik %A Petrosino, Joe %A Points, Gary L %A Carolyn M Poutasse %A Diana Rohlman %A Richard P Scott %A Brian W Smith %A Lane G Tidwell %A Cheryl Walker %A Katrina M Waters %A Kim A Anderson %B EMT Research Day, Corvallis, OR %C Corvallis, OR %8 01/2019 %G eng %0 Journal Article %J R Soc Open Sci %D 2019 %T Discovery of common chemical exposures across three continents using silicone wristbands. %A Holly Dixon %A Armstrong, Georgina %A Michael L Barton %A Alan J Bergmann %A Melissa Bondy %A Mary L Halbleib %A Winnifred Hamilton %A Erin N Haynes %A Julie Herbstman %A Peter D Hoffman %A Paul C Jepson %A Molly Kile %A Laurel D Kincl %A Paul J Laurienti %A Paula E North %A Paulik, L Blair %A Petrosino, Joe %A Points, Gary L %A Carolyn M Poutasse %A Diana Rohlman %A Richard P Scott %A Brian W Smith %A Lane G Tidwell %A Cheryl Walker %A Katrina M Waters %A Kim A Anderson %X

To assess differences and trends in personal chemical exposure, volunteers from 14 communities in Africa (Senegal, South Africa), North America (United States (U.S.)) and South America (Peru) wore 262 silicone wristbands. We analysed wristband extracts for 1530 unique chemicals, resulting in 400 860 chemical data points. The number of chemical detections ranged from 4 to 43 per wristband, with 191 different chemicals detected, and 1339 chemicals were not detected in any wristband. No two wristbands had identical chemical detections. We detected 13 potential endocrine disrupting chemicals in over 50% of all wristbands and found 36 chemicals in common between chemicals detected in three geographical wristband groups (Africa, North America and South America). U.S. children (less than or equal to 11 years) had the highest percentage of flame retardant detections compared with all other participants. Wristbands worn in Texas post-Hurricane Harvey had the highest mean number of chemical detections (28) compared with other study locations (10-25). Consumer product-related chemicals and phthalates were a high percentage of chemical detections across all study locations (36-53% and 18-42%, respectively). Chemical exposures varied among individuals; however, many individuals were exposed to similar chemical mixtures. Our exploratory investigation uncovered personal chemical exposure trends that can help prioritize certain mixtures and chemical classes for future studies.

%B R Soc Open Sci %V 6 %P 181836 %8 02/2019 %G eng %N 2 %R 10.1098/rsos.181836 %0 Generic %D 2019 %T Discovery of Firefighter chemical Exposures Using Military-Style Silicone Dog Tags %A Carolyn M Poutasse %A Walker S Carlos Poston %A Sara A Jahnke %A Christopher K Haddock %A Lane G Tidwell %A Kim A Anderson %B Military Health System Research Symposium, Kissimmee, FL %8 08/2019 %G eng %0 Generic %D 2019 %T Discovery of Firefighter Chemical Exposures using Military-Style Silicone Dog Tags %A Carolyn M Poutasse %A Walker S Carlos Poston %A Sara A Jahnke %A Christopher K Haddock %A Lane G Tidwell %A Kim A Anderson %B SETAC North America 40th Annual Meeting, Toronto, ON %8 11/2019 %G eng %0 Journal Article %J Anal Bioanal Chem %D 2018 %T Development of quantitative screen for 1550 chemicals with GC-MS. %A Alan J Bergmann %A Points, Gary L %A Richard P Scott %A Glenn R Wilson %A Kim A Anderson %X

With hundreds of thousands of chemicals in the environment, effective monitoring requires high-throughput analytical techniques. This paper presents a quantitative screening method for 1550 chemicals based on statistical modeling of responses with identification and integration performed using deconvolution reporting software. The method was evaluated with representative environmental samples. We tested biological extracts, low-density polyethylene, and silicone passive sampling devices spiked with known concentrations of 196 representative chemicals. A multiple linear regression (R = 0.80) was developed with molecular weight, logP, polar surface area, and fractional ion abundance to predict chemical responses within a factor of 2.5. Linearity beyond the calibration had R > 0.97 for three orders of magnitude. Median limits of quantitation were estimated to be 201 pg/μL (1.9× standard deviation). The number of detected chemicals and the accuracy of quantitation were similar for environmental samples and standard solutions. To our knowledge, this is the most precise method for the largest number of semi-volatile organic chemicals lacking authentic standards. Accessible instrumentation and software make this method cost effective in quantifying a large, customizable list of chemicals. When paired with silicone wristband passive samplers, this quantitative screen will be very useful for epidemiology where binning of concentrations is common. Graphical abstract A multiple linear regression of chemical responses measured with GC-MS allowed quantitation of 1550 chemicals in samples such as silicone wristbands.

%B Anal Bioanal Chem %V 410 %P 3101-3110 %8 2018 May %G eng %N 13 %R 10.1007/s00216-018-0997-7 %0 Generic %D 2018 %T Discovery of common chemical exposures across three continents using silicone wristbands %A Holly Dixon %A Armstrong, Georgina %A Michael L Barton %A Bergmann AJ %A Melissa Bondy %A Mary L Halbleib %A Erin N Haynes %A Julie Herbstman %A Winnifred Hamilton %A Peter D Hoffman %A Paul C Jepson %A Molly Kile %A Laurel D Kincl %A Paul J Laurienti %A Paula E North %A LB Paulik %A Petrosino, Joe %A Points, Gary L %A Carolyn M Poutasse %A Diana Rohlman %A Richard P Scott %A Brian W Smith %A Lane G Tidwell %A Cheryl Walker %A Katrina M Waters %A Kim A Anderson %B FSES External Advisory Committee Meeting, Yachats, OR %8 10/2018 %G eng %0 Generic %D 2017 %T Diffusive flux of PAHs across sediment-water and water-air interfaces at urban Superfund sites and economic Implications %A D James Minick %A Kim A Anderson %B American Chemical Socieity National Meeting %8 08/2017 %G eng %0 Journal Article %J Environ Toxicol Chem %D 2017 %T Diffusive flux of PAHs across sediment-water and water-air interfaces at urban superfund sites. %A D James Minick %A Kim A Anderson %K Air %K Cities %K Geologic Sediments %K Hazardous Waste Sites %K Oregon %K Polycyclic Aromatic Hydrocarbons %K Rivers %K Water %K Water Pollutants, Chemical %X

Superfund sites may be a source of polycyclic aromatic hydrocarbons (PAHs) to the surrounding environment. These sites can also act as PAH sinks from present-day anthropogenic activities, especially in urban locations. Understanding PAH transport across environmental compartments helps to define the relative contributions of these sources and is therefore important for informing remedial and management decisions. In the present study, paired passive samplers were co-deployed at sediment-water and water-air interfaces within the Portland Harbor Superfund Site and the McCormick and Baxter Superfund Site. These sites, located along the Willamette River (Portland, OR, USA), have PAH contamination from both legacy and modern sources. Diffusive flux calculations indicate that the Willamette River acts predominantly as a sink for low molecular weight PAHs from both the sediment and the air. The sediment was also predominantly a source of 4- and 5-ring PAHs to the river, and the river was a source of these same PAHs to the air, indicating that legacy pollution may be contributing to PAH exposure for residents of the Portland urban center. At the remediated McCormick and Baxter Superfund Site, flux measurements highlight locations within the sand and rock sediment cap where contaminant breakthrough is occurring. Environ Toxicol Chem 2017;36:2281-2289. © 2017 SETAC.

%B Environ Toxicol Chem %V 36 %P 2281-2289 %8 2017 09 %G eng %N 9 %R 10.1002/etc.3785 %0 Generic %D 2016 %T Diffusive flux of PAHs across sediment, water, and air interfaces at urban Superfund Sites %A D James Minick %E Kim A Anderson %B SETAC North America 37th Annual Meeting, Orlando, Florida %8 11/2016 %G eng %0 Audiovisual Material %D 2016 %T Diffusive flux of PAHs across sediment, water, and air interfaces at urban Superfund Sites %A D James Minick %E Kim A Anderson %B NIEHS FEST %C Durham, NC %8 12/2016 %G eng %0 Generic %D 2016 %T Distribution of chemical exposures in rural Peru using silicone wristbands %A Alan J Bergmann %A Paula E North %A Vasquez, Luis %A Bello, Hernan %A Maria del Carmen Ruiz %A Kim A Anderson %B Environmental Health Sciences and Superfund Research Program Colloquium %8 10/2016 %G eng %0 Audiovisual Material %D 2016 %T Distribution of multi-class chemical exposure in rural Peru measured with silicone wristbands %A Alan J Bergmann %A Paula E North %A Vasquez, Luis %A Bello, Hernan %A Maria del Carmen Ruiz %A Kim A Anderson %B Society of Environmental Toxicology and Chemistry %8 11/2016 %G eng %0 Audiovisual Material %D 2015 %T Development of an online platform to promote environmental public health within citizen scientists %A Diana Rohlman %A Kevin A Hobbie %A Michael L Barton %A Josh A Willmarth %A Laurel D Kincl %A Kim A Anderson %B SETAC North America 36th Annual Meeting. Salt Lake City, Utah %8 11/2015 %G eng %0 Generic %D 2015 %T Disasters and Emerging Environmental Threats %A Miller, A %A Kim A Anderson %A Erin N Haynes %A Lefthand-Begay, C %A O’Fallon, L %A Kwok, R %B 25th Annual Meeting of the International Society for Exposure Science. Henderson, Nevada %8 10/2015 %G eng %0 Generic %D 2015 %T Distinguished Provost's Graduate Fellowship %A Carolyn M Poutasse %B Oregon State University, Corvallis, OR %8 09/2015 %G eng %0 Generic %D 2014 %T Detecting, Assessing, and Improving Understanding of Environmental Health Risks though Citizen Scientists and Passive Sampling Technologies %A Kim A Anderson %B National Academy of Sciences sponsored, Community Resilience and Health Opportunity Analysis Workshop. New Orleans, LA %8 09/2014 %G eng %0 Audiovisual Material %D 2012 %T Development and Validation of Complementary LCMS and GCMS Methods to Examine Oxygenated-PAHs (OPAHs) in Environmental Mixtures %A Steven G O'Connell %A Theodore A Haigh %A Glenn R Wilson %A Kim A Anderson %B 25th Annual Meeting of the Superfund Research Program %8 10/2012 %G eng %0 Journal Article %J J Agric Food Chem %D 2011 %T Determination of parent and substituted polycyclic aromatic hydrocarbons in high-fat salmon using a modified QuEChERS extraction, dispersive SPE and GC-MS. %A Norman D Forsberg %A Glenn R Wilson %A Kim A Anderson %K Animals %K Fats %K Food Contamination %K Gas Chromatography-Mass Spectrometry %K Polycyclic Hydrocarbons, Aromatic %K Salmon %K Seafood %K Solid Phase Extraction %X

A fast and easy modified QuEChERS (quick, easy, cheap, rugged and safe) extraction method has been developed and validated for determination of 33 parent and substituted polycyclic aromatic hydrocarbons (PAHs) in high-fat smoked salmon that greatly enhances analyte recovery compared to traditional QuEChERS procedures. Sample processing includes extraction of PAHs into a solution of ethyl acetate, acetone and isooctane followed by cleanup with dispersive SPE and analysis by GC-MS in SIM mode. Method performance was assessed in spike recovery experiments (500 μg/g wet weight) in three commercially available smoked salmon with 3-11% fat. Recoveries of some 2-, 3- and 5-ring PAHs were improved 50-200% over traditional methods, while average recovery across all PAHs was improved 67%. Method precision was good with replicate extractions typically yielding relative standard deviations <10%, and detection limits were in the low ng/g range. With this method, a single analyst could extract and clean up ≥60 samples for PAH analysis in an 8 h work day.

%B J Agric Food Chem %V 59 %P 8108-16 %8 08/2011 %G eng %N 15 %1 http://www.ncbi.nlm.nih.gov/pubmed/21732651?dopt=Abstract %R 10.1021/jf201745a %0 Audiovisual Material %D 2011 %T Development of modified QuEChERS extraction methods for the analysis of PAHs in high fat content fish and smoked salmon %A Norman D Forsberg %A Glenn R Wilson %A Kim A Anderson %B SETAC North America 32nd Annual Conference %8 11/2011 %G eng %0 Audiovisual Material %D 2011 %T Development of modified QuEChERS extraction methods for the analysis of PAHs in high fat content fish and smoked salmon %A Norman D Forsberg %A Glenn R Wilson %A Kim A Anderson %B Superfund External Advisory Council Meeting %8 2011 %G eng %0 Audiovisual Material %D 2011 %T Developmental toxicity of bioavailable contaminants from the Portland Harbor Superfund site: Bridging environmental mixtures and toxic effects %A Sarah E Allan %A Robyn L Tanguay %A Kim A Anderson %B SETAC North America 32nd Annual Conference %8 11/2011 %G eng %0 Generic %D 2010 %T Deepwater Horizon Disaster %A Kim A Anderson %B NIEHS Webinar %8 2010 %G eng %0 Audiovisual Material %D 2010 %T Deepwater Horizon oil spill sites used to demonstrate atmospheric passive samplers coupled with a 1200 analyte screening method %A Lane G Tidwell %A Kevin A Hobbie %A Sarah E Allan %A Steven G O'Connell %A Glenn R Wilson %A Kim A Anderson %B SETAC North America 31st Annual Conference %I SETAC North America 31st Annual Conference %8 11/2010 %G eng %0 Generic %D 2010 %T Demonstrating Silicone Passive Samplers in a Model Urban Harbor and Superfund Site for a Suite of Semi-polar Organic Contaminants %A Steven G O'Connell %B SETAC North America 31st Annual Conference %8 2010 %G eng %0 Audiovisual Material %D 2010 %T Determination of the Historical Contributions of Fertilizer Applications to the Bioavailable Metal Concentrations in Oregon Agricultural Soils %A Lane G Tidwell %A Kevin A Hobbie %A Perez, Angela L %A Kim A Anderson %B SETAC North America 31st Annual Conference %8 2010 %G eng %0 Journal Article %J Environ Health Perspect %D 2009 %T Developmental exposure to polychlorinated biphenyls interferes with experience-dependent dendritic plasticity and ryanodine receptor expression in weanling rats. %A Yang, Dongren %A Kim, Kyung Ho %A Phimister, Andrew %A Bachstetter, Adam D %A Ward, Thomas R %A Stackman, Robert W %A Mervis, Ronald F %A Wisniewski, Amy B %A Klein, Sabra L %A Kodavanti, Prasada Rao S %A Kim A Anderson %A Wayman, Gary %A Pessah, Isaac N %A Lein, Pamela J %K Animals %K Animals, Newborn %K Body Weight %K Chlorodiphenyl (54% Chlorine) %K Dendrites %K Female %K Gene Expression Regulation, Developmental %K Green Fluorescent Proteins %K Litter Size %K Maze Learning %K Memory %K Microtubule-Associated Proteins %K Neuronal Plasticity %K Pregnancy %K Prenatal Exposure Delayed Effects %K Rats %K Rats, Sprague-Dawley %K Ryanodine Receptor Calcium Release Channel %K Sex Ratio %X

BACKGROUND: Neurodevelopmental disorders are associated with altered patterns of neuronal connectivity. A critical determinant of neuronal connectivity is the dendritic morphology of individual neurons, which is shaped by experience. The identification of environmental exposures that interfere with dendritic growth and plasticity may, therefore, provide insight into environmental risk factors for neurodevelopmental disorders.

OBJECTIVE: We tested the hypothesis that polychlorinated biphenyls (PCBs) alter dendritic growth and/or plasticity by promoting the activity of ryanodine receptors (RyRs).

METHODS AND RESULTS: The Morris water maze was used to induce experience-dependent neural plasticity in weanling rats exposed to either vehicle or Aroclor 1254 (A1254) in the maternal diet throughout gestation and lactation. Developmental A1254 exposure promoted dendritic growth in cerebellar Purkinje cells and neocortical pyramidal neurons among untrained animals but attenuated or reversed experience-dependent dendritic growth among maze-trained littermates. These structural changes coincided with subtle deficits in spatial learning and memory, increased [3H]-ryanodine binding sites and RyR expression in the cerebellum of untrained animals, and inhibition of training-induced RyR upregulation. A congener with potent RyR activity, PCB95, but not a congener with negligible RyR activity, PCB66, promoted dendritic growth in primary cortical neuron cultures and this effect was blocked by pharmacologic antagonism of RyR activity.

CONCLUSIONS: Developmental exposure to PCBs interferes with normal patterns of dendritic growth and plasticity, and these effects may be linked to changes in RyR expression and function. These findings identify PCBs as candidate environmental risk factors for neurodevelopmental disorders, especially in children with heritable deficits in calcium signaling.

%B Environ Health Perspect %V 117 %P 426-35 %8 03/2009 %G eng %N 3 %1 http://www.ncbi.nlm.nih.gov/pubmed/19337518?dopt=Abstract %R 10.1289/ehp.11771 %0 Journal Article %J Sci Total Environ %D 2009 %T DGT estimates cadmium accumulation in wheat and potato from phosphate fertilizer applications. %A Perez, Angela L %A Kim A Anderson %K Cadmium %K Diffusion %K Fertilizers %K Phosphates %K Quality Control %K Solanum tuberosum %K Triticum %X

Cadmium is a common impurity in phosphatic fertilizers and may contribute to soil Cd accumulation. Changes in total and bioavailable Cd burdens to agricultural soils and the potential for plant Cd accumulation resulting from fertilizer input was investigated. Three year field studies were conducted using three dose levels of cadmium-rich, commercial, phosphate fertilizers applied at four agricultural sites. Labile Cd concentrations, measured using the passive sampling device Diffusive Gradients in Thin Films (Cd(DGT)), increased with increasing fertilizer application rates. Cd also accumulated in the edible portion of wheat and potato crops grown at the sites, and showed strong positive dose response with fertilizer treatment. Regression models were calculated for each site, year, and for individual crops. Model comparisons indicated that soil physical and chemical parameters in addition to soil Cd fractions, were important determinants of Cd(DGT). Significant factors contributing to Cd(DGT) concentrations were Cd from fertilizer input (Cd(fertilizer)), pH, cation exchange capacity (CEC), and total recoverable Cd (Cd(total)). Important factors used to determine Cd concentrations in wheat grain (Cd(wheat)) and in potato (Cd(potato)) were as follows: Cd(wheat):Cd(fertilizer), and Cd(DGT); and Cd(potato):Cd(fertilizer), Cd(DGT), % O.M. The effective concentration, C(E), calculated from DGT did not correlate well with Cd(wheat) or with Cd(potato). Direct measurements of Cd(DGT) correlated better with Cd found in edible plant tissue. The modeling approach presented in this study helps to estimate Cd accumulation in plant tissue over multiple years and in distinct agricultural soil systems.

%B Sci Total Environ %V 407 %P 5096-103 %8 09/2009 %G eng %N 18 %1 http://www.ncbi.nlm.nih.gov/pubmed/19552942?dopt=Abstract %R 10.1016/j.scitotenv.2009.05.045 %0 Journal Article %J DNA Repair (Amst) %D 2005 %T Discrimination and versatility in mismatch repair. %A John B Hays %A Peter D Hoffman %A Wang, Huixian %K Base Pair Mismatch %K DNA %K DNA Repair %K HeLa Cells %K Humans %K MutS DNA Mismatch-Binding Protein %K Protein Binding %K Substrate Specificity %X

Evolutionarily-conserved mismatch-repair (MMR) systems correct all or almost all base-mismatch errors from DNA replication via excision-resynthesis pathways, and respond to many different DNA lesions. Consideration of DNA polymerase error rates and possible consequences of excess gratuitous excision of perfectly paired (homoduplex) DNA in vivo suggests that MMR needs to discriminate against homoduplex DNA by three to six orders of magnitude. However, numerous binding studies using MMR base-mispair-recognition proteins, bacterial MutS or eukaryotic MSH2.MSH6 (MutSalpha), have typically shown discrimination factors between mismatched and homoduplex DNA to be 5-30, depending on the binding conditions, the particular mismatches, and the DNA-sequence contexts. Thus, downstream post-binding steps must increase MMR discrimination without interfering with the versatility needed to recognize a large variety of base-mismatches and lesions. We use a complex but highly MMR-active model system, human nuclear extracts mixed with plasmid substrates containing specific mismatches and defined nicks 0.15 kbp away, to measure the earliest quantifiable committed step in mismatch correction, initiation of mismatch-provoked 3'-5' excision at the nicks. We compared these results to binding of purified MutSalpha to synthetic oligoduplexes containing the same mismatches in the same sequence contexts, under conditions very similar to those prevailing in the nuclear extracts. Discrimination against homoduplex DNA, only two-to five-fold in the binding studies, increased to 60- to 230-fold or more for excision initiation, depending on the particular mismatches. Remarkably, the mismatch-preference order for excision initiation was substantially altered from the order for hMutSalpha binding. This suggests that post-binding steps not only strongly discriminate against homoduplex DNA, but do so by mechanisms not tightly constrained by initial binding preferences. Pairs of homoduplexes (40, 50, and 70 bp) prepared from synthetic oligomers or cut out of plasmids showed virtually identical hMutSalpha binding affinities, suggesting that high hMutSalpha binding to homoduplex DNA is not the result of misincorporations or lesions introduced during chemical synthesis. Intrinsic affinities of MutS homologs for perfectly paired DNA may help these proteins efficiently position themselves to carry out subsequent mismatch-specific steps in MMR pathways.

%B DNA Repair (Amst) %V 4 %P 1463-74 %8 2005 Dec 08 %G eng %N 12 %R 10.1016/j.dnarep.2005.09.002 %0 Journal Article %J J AOAC Int %D 2003 %T Determination of pyrethrin and pyrethroid pesticides in urine and water matrixes by liquid chromatography with diode array detection. %A Loper, Bobby R %A Kim A Anderson %K Calibration %K Chromatography, Liquid %K Humans %K Indicators and Reagents %K Insecticides %K Pyrethrins %K Reference Standards %K Spectrometry, Mass, Electrospray Ionization %K Spectrophotometry, Ultraviolet %K Water %X

The following pyrethrin and pyrethroid pesticides were determined in urine and water matrixes by liquid chromatography with diode array detection (LC-DAD): pyrethrin I, pyrethrin II, tetramethrin, baythroid, bifenthrin, fenvalerate, phenothrin, allethrin, resmethrin, cis-permethrin, and trans-permethrin. In addition, 3-phenoxybenzyl alcohol, a metabolite of various pyrethroids, was also successfully determined by the analytical method. The matrix extraction was simple, inexpensive, and fast, using only sodium chloride and acetonitrile. The acetonitrile extract was filtered and analyzed by LC-DAD. The method detection limits for the pyrethrin pesticides in 5 mL urine were determined to range from 0.002 to 0.04 microg/mL, depending on the individual pyrethrin. Recoveries from spiked tap water ranged from 77 to 96%; recoveries from urine ranged from 80 to 117%. This method is especially well-suited to clinical investigations, in which rapid analysis of forensic samples is often required.

%B J AOAC Int %V 86 %P 1236-40 %8 11/2003 %G eng %N 6 %1 http://www.ncbi.nlm.nih.gov/pubmed/14979708?dopt=Abstract %0 Generic %D 2002 %T D.B. DeLoach Research Scholarship Fund %A Padilla, Kimberly L %G eng %0 Audiovisual Material %D 1999 %T Defining Geographic Origin of Foods-apples %A Kim A Anderson %A Brian W Smith %B PITTCON®‘99 Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, Orlando, FL %8 1999 %G eng %0 Audiovisual Material %D 1999 %T Defining the Geographic Origin of Coffee %A Kim A Anderson %A Brian W Smith %B 54th Northwest Regional, American Chemical Society Mtg, Portland, OR %8 1999 %G eng %0 Journal Article %J Ecological Applications %D 1999 %T DNA repair and resistance to UV-B radiation in western spotted frogs %A Andrew R Blaustein %A John B Hays %A Peter D Hoffman %A Chivers, DP %A Kiesecker, J M %A Leonard WP %A Marco, A %A Reaser, JK %A Anthony, RG %B Ecological Applications %8 1999 %G eng %N 9:3:1100-1105 %0 Magazine Article %D 1998 %T Detecting the Geographic Origins of Food %A Jordan, JR %E Brian W Smith %E Kim A Anderson %B Inside Laboratory Management, AOAC International %8 05/1998 %G eng %0 Audiovisual Material %D 1997 %T Defining Geographic Origin of Potatoes with Trace Metal Analysis Using Neural Networks %A Kim A Anderson %A Brian W Smith %B 111th AOAC INTERNATIONAL (Association of Official Analytical Chemists) Annual Meeting & Exposition, San Diego, CA %8 1997 %G eng %0 Report %D 1996 %T Development of a Stable Pulp and Paper Industry Wastewater Reference Material for use in Compliance Monitoring QA/QC Programs %A Cook, D %A LaFleur, L. L. %A Parrish, A %A Jones, J %A Glenn R Wilson %A Hoy, D %B NCASI %G eng %0 Journal Article %J Photochem Photobiol %D 1996 %T Developmental responses of amphibians to solar and artificial UVB sources: a comparative study. %A John B Hays %A Andrew R Blaustein %A Kiesecker, J M %A Peter D Hoffman %A Pandelova, I %A Coyle, D %A Richardson, T %K Amphibians %K Animals %K Deoxyribodipyrimidine Photo-Lyase %K DNA %K DNA Repair %K Female %K Ovum %K Radiation Tolerance %K Sunlight %K Ultraviolet Rays %X

Many amphibian species, in widely scattered locations, currently show population declines and/or reductions in range, but other amphibian species show no such declines. There is no known single cause for these declines. Differential sensitivity to UVB radiation among species might be one contributing factor. We have focused on amphibian eggs, potentially the most UVB-sensitive stage, and compared their resistance to UVB components of sunlight with their levels of photolyase, typically the most important enzyme for repair of the major UV photoproducts in DNA, cyclobutane pyrimidine dimers. Photolyase varied 100-fold among eggs/oocytes of 10 species. Among three species-Hyla regilla, Rana cascadae, and Bufo boreas-for which resistance of eggs to solar UVB irradiance in their natural locations was measured, hatching success correlated strongly with photolyase. Two additional species, Rana aurora and Ambystoma gracile, now show similar correlations. Among the low-egg-photolyase species, R. cascadae and B. boreas are showing declines, and the status of A. gracile is not known. Of the two high-photolyase species, populations of H. regilla remain robust, but populations of R. aurora are showing declines. To determine whether levels of photolyase or other repair activities are affected by solar exposures during amphibian development, we have initiated an extended study of H. regilla and R. cascadae, and of Xenopus laevis, laboratory-reared specimens of which previously showed very low photolyase levels. Hyla regilla and R. cascadae tadpoles are being reared to maturity in laboratories supplemented with modest levels of UV light or light filtered to remove UVB wavelengths. Young X. laevis females are being reared indoors and outdoors. Initial observations reveal severe effects of both UVA and UVB light on H. regilla and R. cascadae tadpoles and metamorphs, including developmental abnormalities and high mortalities. Assays of photolyase levels in the skins of young animals roughly parallel previous egg/oocyte photolyase measurements for all three species.

%B Photochem Photobiol %V 64 %P 449-56 %8 1996 Sep %G eng %N 3 %0 Journal Article %J Journal of Cellular Biochemistry %D 1995 %T Differences in DNA-repair activity and sensitivity to UV-B light among eggs and oocytes of declining and stable amphibian species %A John B Hays %A Peter D Hoffman %A Andrew R Blaustein %B Journal of Cellular Biochemistry %8 1995 %G eng %N 296 %0 Generic %D 0 %T D.B. DeLoach Research Scholarship Fund %A Visalli, Solyssa %G eng