%0 Journal Article %J Arch Environ Occup Health %D 2023 %T Chemical contaminant exposures assessed using silicone wristbands among fuel station attendants, taxi drivers and commercial motorcycle riders in Kampala, Uganda. %A Atusingwize, Edwinah %A Diana Rohlman %A Peter D Hoffman %A Wafula, Solomon Tsebeni %A Musoke, David %A Buregyeya, Esther %A Mugambe, Richard K %A Ndejjo, Rawlance %A Ssempebwa, John C %A Kim A Anderson %X

There are concerns over traffic-related air pollution in Uganda's capital, Kampala. Individuals in the transportation sector are hypothesized to be at greater risk for exposure to volatile organic compounds, given their proximity to vehicle exhaust. Silicone wristbands are a wearable technology that passively sample individuals' chemical exposures. We conducted a pilot cross sectional study to measure personal exposures to volatile organic compounds among 14 transportation workers who wore a wristband for five days. We analyzed for 75 volatile organic compounds; 33 chemicals (35%) were detected and quantified in at least 50% of the samples and 15 (16%) chemicals were detected and quantified across all the samples. Specific chemicals were associated with participants' occupation. The findings can guide future large studies to inform policy and practice to reduce exposure to chemicals in the environment in Kampala.

%B Arch Environ Occup Health %P 1-11 %8 2023 Nov 02 %G eng %R 10.1080/19338244.2023.2275144 %0 Journal Article %J Sci Total Environ %D 2019 %T Determinants of pesticide concentrations in silicone wristbands worn by Latina adolescent girls in a California farmworker community: The COSECHA youth participatory action study. %A Harley, Kim G %A Parra, Kimberly L %A Jose Camacho %A Asa Bradman %A Nolan, James E S %A Lessard, Chloe %A Kim A Anderson %A Carolyn M Poutasse %A Richard P Scott %A Lazaro, Giselle %A Edgar Cardoso %A Daisy Gallardo %A Gunier, Robert B %X

Personal exposure to pesticides has not been well characterized, especially among adolescents. We used silicone wristbands to assess pesticide exposure in 14 to 16 year old Latina girls (N = 97) living in the agricultural Salinas Valley, California, USA and enrolled in the COSECHA (CHAMACOS of Salinas Examining Chemicals in Homes and Agriculture) Study, a youth participatory action study in an agricultural region of California. We determined pesticide concentrations (ng/g/day) in silicone wristbands worn for one week using gas chromatography electron capture detection and employed gas chromatography mass spectrometry to determine the presence or absence of over 1500 chemicals. Predictors of pesticide detections and concentrations were identified using logistic regression, Wilcoxon rank sum tests, and Tobit regression models. The most frequently detected pesticides in wristbands were fipronil sulfide (87%), cypermethrin (56%), dichlorodiphenyldichloroethylene (DDE) (56%), dacthal (53%), and trans-permethrin (52%). Living within 100 m of active agricultural fields, having carpeting in the home, and having an exterminator treat the home in the past six months were associated with higher odds of detecting certain pesticides. Permethrin concentrations were lower for participants who cleaned their homes daily (GM: 1.9 vs. 6.8 ng/g/day, p = 0.01). In multivariable regression models, participants with doormats in the entryway of their home had lower concentrations (p < 0.05) of cypermethrin (87%), permethrin (99%), fipronil sulfide (69%) and DDE (75%). The results suggest that both nearby agricultural pesticide use and individual behaviors are associated with pesticide exposures.

%B Sci Total Environ %V 652 %P 1022-1029 %8 2018 Oct 23 %G eng %R 10.1016/j.scitotenv.2018.10.276 %0 Journal Article %J Chemosphere %D 2019 %T Differential exposure to organophosphate flame retardants in mother-child pairs. %A Gibson, Elizabeth A %A Heather M Stapleton %A Lehyla Calero %A Darrell Holmes %A Burke, Kimberly %A Martinez, Rodney %A Cortes, Boris %A Nematollahi, Amy %A Evans, David %A Kim A Anderson %A Julie Herbstman %K Adult %K Child %K Child Development %K Child, Preschool %K Cohort Studies %K Dust %K Environmental Exposure %K Female %K Flame Retardants %K Humans %K Male %K Mothers %K Organophosphates %K Young Adult %X

BACKGROUND: Humans are ubiquitously exposed to flame retardants, including organophosphate esters (OPEs), through direct contact with consumer products or exposure through household dust. Children are at increased risk because of their proximity to dust, hand-to-mouth activity, and the importance of childhood as a critical period in neurodevelopment.

OBJECTIVES: To quantify differences in exposure levels between mothers and children (three to six years of age), we analyzed urinary metabolites of OPEs. We additionally assessed the ability of silicone wristbands (measuring ambient exposure) to predict urinary metabolite concentrations.

METHODS: We selected 32 mother and child dyads from an existing cohort. Participants provided baseline urine samples and wore wristbands for one week. After the first week, they returned their wristbands and provided a second urine sample. During the second week, participants wore a second wristband that they returned at the end of week two with a third and final urine sample.

RESULTS: We found significantly higher levels of bis(1,3-dichloro-2-propyl) phosphate (BDCIPP) (p < 0.001) and lower levels of bis(1-chloro-2-isopropyl) 1-hydroxy-2-propyl phosphate (BCIPHIPP) (p < 0.001) in children's urine samples compared to mothers' samples at baseline. We found that triphenylphosphate (TPHP), tris(1,3-dichloroisopropyl) phosphate (TDCIPP), and tris(1-chloro-2-propyl) phosphate (TCIPP) measured in wristbands predicted their respective metabolite levels in urine.

CONCLUSION: Children had higher levels than mothers for two of six flame retardant metabolites measured in urine. Generally, wristband measurements positively predicted internal dose. As little is known about the health effects of OPEs on child development, future research is needed to determine the impact of differential exposure.

%B Chemosphere %V 219 %P 567-573 %8 2019 Mar %G eng %R 10.1016/j.chemosphere.2018.12.008 %0 Audiovisual Material %D 2019 %T Discovery of common chemical exposures across three continents using silicone wristbands %A Holly Dixon %A Armstrong, Georgina %A Michael L Barton %A Alan J Bergmann %A Melissa Bondy %A Mary L Halbleib %A Erin N Haynes %A Julie Herbstman %A Winnifred Hamilton %A Peter D Hoffman %A Paul C Jepson %A Molly Kile %A Laurel D Kincl %A Paul J Laurienti %A Paula E North %A LB Paulik %A Petrosino, Joe %A Points, Gary L %A Carolyn M Poutasse %A Diana Rohlman %A Richard P Scott %A Brian W Smith %A Lane G Tidwell %A Cheryl Walker %A Katrina M Waters %A Kim A Anderson %B EMT Research Day, Corvallis, OR %C Corvallis, OR %8 01/2019 %G eng %0 Journal Article %J R Soc Open Sci %D 2019 %T Discovery of common chemical exposures across three continents using silicone wristbands. %A Holly Dixon %A Armstrong, Georgina %A Michael L Barton %A Alan J Bergmann %A Melissa Bondy %A Mary L Halbleib %A Winnifred Hamilton %A Erin N Haynes %A Julie Herbstman %A Peter D Hoffman %A Paul C Jepson %A Molly Kile %A Laurel D Kincl %A Paul J Laurienti %A Paula E North %A Paulik, L Blair %A Petrosino, Joe %A Points, Gary L %A Carolyn M Poutasse %A Diana Rohlman %A Richard P Scott %A Brian W Smith %A Lane G Tidwell %A Cheryl Walker %A Katrina M Waters %A Kim A Anderson %X

To assess differences and trends in personal chemical exposure, volunteers from 14 communities in Africa (Senegal, South Africa), North America (United States (U.S.)) and South America (Peru) wore 262 silicone wristbands. We analysed wristband extracts for 1530 unique chemicals, resulting in 400 860 chemical data points. The number of chemical detections ranged from 4 to 43 per wristband, with 191 different chemicals detected, and 1339 chemicals were not detected in any wristband. No two wristbands had identical chemical detections. We detected 13 potential endocrine disrupting chemicals in over 50% of all wristbands and found 36 chemicals in common between chemicals detected in three geographical wristband groups (Africa, North America and South America). U.S. children (less than or equal to 11 years) had the highest percentage of flame retardant detections compared with all other participants. Wristbands worn in Texas post-Hurricane Harvey had the highest mean number of chemical detections (28) compared with other study locations (10-25). Consumer product-related chemicals and phthalates were a high percentage of chemical detections across all study locations (36-53% and 18-42%, respectively). Chemical exposures varied among individuals; however, many individuals were exposed to similar chemical mixtures. Our exploratory investigation uncovered personal chemical exposure trends that can help prioritize certain mixtures and chemical classes for future studies.

%B R Soc Open Sci %V 6 %P 181836 %8 02/2019 %G eng %N 2 %R 10.1098/rsos.181836 %0 Audiovisual Material %D 2018 %T Comparing chemical exposures across diverse communities using silicone wristbands %A Holly Dixon %A Alan J Bergmann %A Mary L Halbleib %A Erin N Haynes %A Julie Herbstman %A Peter D Hoffman %A Paul C Jepson %A Molly Kile %A Laurel D Kincl %A Paul J Laurienti %A Paula E North %A LB Paulik %A Points, Gary L %A Carolyn M Poutasse %A Diana Rohlman %A Richard P Scott %A Smith BW %A Lane G Tidwell %A Katrina M Waters %A Kim A Anderson %B 3rd Tribal Environmental Health Summit, Corvallis, OR %C Corvallis, Oregon %8 06/2018 %G eng %0 Audiovisual Material %D 2018 %T Comparing Chemical Exposures Across Diverse Communities Using Silicone Wristbands %A Holly Dixon %A Bergmann AJ %A Mary L Halbleib %A Erin N Haynes %A Julie Herbstman %A Peter D Hoffman %A Paul C Jepson %A Molly Kile %A Laurel D Kincl %A Paul J Laurienti %A Paula E North %A LB Paulik %A Points, Gary L %A Carolyn M Poutasse %A Diana Rohlman %A Richard P Scott %A Brian W Smith %A Lane G Tidwell %A Katrina M Waters %A Kim A Anderson %B Total Exposure Health Conference, Bethesda, MD %8 09/2018 %G eng %0 Generic %D 2018 %T Discovery of common chemical exposures across three continents using silicone wristbands %A Holly Dixon %A Armstrong, Georgina %A Michael L Barton %A Bergmann AJ %A Melissa Bondy %A Mary L Halbleib %A Erin N Haynes %A Julie Herbstman %A Winnifred Hamilton %A Peter D Hoffman %A Paul C Jepson %A Molly Kile %A Laurel D Kincl %A Paul J Laurienti %A Paula E North %A LB Paulik %A Petrosino, Joe %A Points, Gary L %A Carolyn M Poutasse %A Diana Rohlman %A Richard P Scott %A Brian W Smith %A Lane G Tidwell %A Cheryl Walker %A Katrina M Waters %A Kim A Anderson %B FSES External Advisory Committee Meeting, Yachats, OR %8 10/2018 %G eng %0 Journal Article %J Annu Rev Public Health %D 2017 %T Assessing the Exposome with External Measures: Commentary on the State of the Science and Research Recommendations. %A Turner, Michelle C %A Nieuwenhuijsen, Mark %A Kim A Anderson %A Balshaw, David %A Cui, Yuxia %A Dunton, Genevieve %A Hoppin, Jane A %A Koutrakis, Petros %A Jerrett, Michael %X

The exposome comprises all environmental exposures that a person experiences from conception throughout the life course. Here we review the state of the science for assessing external exposures within the exposome. This article reviews (a) categories of exposures that can be assessed externally, (b) the current state of the science in external exposure assessment, (c) current tools available for external exposure assessment, and (d) priority research needs. We describe major scientific and technological advances that inform external assessment of the exposome, including geographic information systems; remote sensing; global positioning system and geolocation technologies; portable and personal sensing, including smartphone-based sensors and assessments; and self-reported questionnaire assessments, which increasingly rely on Internet-based platforms. We also discuss priority research needs related to methodological and technological improvement, data analysis and interpretation, data sharing, and other practical considerations, including improved assessment of exposure variability as well as exposure in multiple, critical life stages.

%B Annu Rev Public Health %V 38 %P 215-239 %8 2017 Mar 20 %G eng %R 10.1146/annurev-publhealth-082516-012802 %0 Journal Article %J J Expo Sci Environ Epidemiol %D 2017 %T Multi-class chemical exposure in rural Peru using silicone wristbands. %A Alan J Bergmann %A Paula E North %A Vasquez, Luis %A Bello, Hernan %A Maria del Carmen Ruiz %A Kim A Anderson %X

Exposure monitoring with personal silicone wristband samplers was demonstrated in Peru in four agriculture and urban communities where logistic and practical constraints hinder use of more traditional approaches. Wristbands and associated methods enabled quantitation of 63 pesticides and screening for 1397 chemicals including environmental contaminants and personal care products. Sixty-eight wristbands were worn for approximately one month by volunteers from four communities of Alto Mayo, Peru. We identified 106 chemicals from eight chemical classes among all wristbands. Agricultural communities were characterized by pesticides and PAHs, while the urban communities had more personal care products present. Multiple linear regressions explained up to 40% of variance in wristbands from chlorpyrifos, cypermethrin, and DDT and its metabolites (DDx) (r(2)=0.39, 0.30, 0.40, respectively). All three pesticides were significantly different between communities, and cypermethrin and DDx were associated with participant age. The calculated relative age of DDT suggested some communities had more recent exposure than others. This work aids health research in the Alto Mayo and beyond by identifying typical mixtures and potential sources of exposure to organic chemicals in the personal environment. Silicone wristband sampling with chemical screening is a candidate for widespread use in exposure monitoring in remote areas.Journal of Exposure Science and Environmental Epidemiology advance online publication, 26 July 2017; doi:10.1038/jes.2017.12.

%B J Expo Sci Environ Epidemiol %8 2017 Jul 26 %G eng %R 10.1038/jes.2017.12 %0 Generic %D 2016 %T Distribution of chemical exposures in rural Peru using silicone wristbands %A Alan J Bergmann %A Paula E North %A Vasquez, Luis %A Bello, Hernan %A Maria del Carmen Ruiz %A Kim A Anderson %B Environmental Health Sciences and Superfund Research Program Colloquium %8 10/2016 %G eng %0 Audiovisual Material %D 2016 %T Distribution of multi-class chemical exposure in rural Peru measured with silicone wristbands %A Alan J Bergmann %A Paula E North %A Vasquez, Luis %A Bello, Hernan %A Maria del Carmen Ruiz %A Kim A Anderson %B Society of Environmental Toxicology and Chemistry %8 11/2016 %G eng %0 Generic %D 2016 %T Personal passive sampling in Peru: Distribution and sources of diverse chemicals measured with silicone wristbands %A Alan J Bergmann %A Paula E North %A Vasquez, Luis %A Bello, Hernan %A Maria del Carmen Ruiz %A Kim A Anderson %B International Society of Exposure Science %8 10/2016 %G eng %0 Generic %D 2015 %T Passive sampling in ambient and individuals' environments in rural Peru %A Alan J Bergmann %A Vasquez, Luis %A Paula E North %A Kim A Anderson %B SETAC North America 36th Annual Meeting. Salt Lake City, Utah %8 11/2015 %G eng %0 Generic %D 2015 %T Passive sampling in ambient and individuals' environments in rural Peru %A Alan J Bergmann %E Vasquez, Luis %E Paula E North %E Kim A Anderson %B FSES External Advisory Committee Meeting %8 10/2015 %G eng %0 Audiovisual Material %D 2014 %T Passive Sampling Devices Enable Capacity Building and Characterization of Bioavailable Mixtures along the Niger, Senegal and Bani Rivers of Africa %A Kim A Anderson %A Seck, Dogo %A Kevin A Hobbie %A Traore, AN %A McCartney, Melissa A %A Ndaye, A %A Norman D Forsberg %A Gregory J Sower %B Society of Toxicology 53rd Annual Meeting, Phoenix, AZ %8 03/2014 %G eng %0 Journal Article %J Philos Trans R Soc Lond B Biol Sci %D 2014 %T Passive sampling devices enable capacity building and characterization of bioavailable pesticide along the Niger, Senegal and Bani Rivers of Africa. %A Kim A Anderson %A Seck, Dogo %A Kevin A Hobbie %A Traore, Anna Ndiaye %A McCartney, Melissa A %A Ndaye, Adama %A Norman D Forsberg %A Gregory J Sower %X

It is difficult to assess pollution in remote areas of less-developed regions owing to the limited availability of energy, equipment, technology, trained personnel and other key resources. Passive sampling devices (PSDs) are technologically simple analytical tools that sequester and concentrate bioavailable organic contaminants from the environment. Scientists from Oregon State University and the Centre Régional de Recherches en Ecotoxicologie et de Sécurité Environnementale (CERES) in Senegal developed a partnership to build capacity at CERES and to develop a pesticide-monitoring project using PSDs. This engagement resulted in the development of a dynamic training process applicable to capacity-building programmes. The project culminated in a field and laboratory study where paired PSD samples were simultaneously analysed in African and US laboratories with quality control evaluation and traceability. The joint study included sampling from 63 sites across six western African countries, generating a 9000 data point pesticide database with virtual access to all study participants.

%B Philos Trans R Soc Lond B Biol Sci %V 369 %P 20130110 %8 04/2014 %G eng %N 1639 %1 http://www.ncbi.nlm.nih.gov/pubmed/24535398?dopt=Abstract %R 10.1098/rstb.2013.0110 %0 Audiovisual Material %D 2012 %T Passive sampling devices (PSDs) and GC-MS screening tools to assess a suite of over 1,000 contaminants in agricultural areas in Western Africa %A Kevin A Hobbie %A McCartney, Melissa A %A Theodore A Haigh %A Glenn R Wilson %A Ndieye, A. %A Seck, Dogo %A Kim A Anderson %X

 

Organizations and developing countries that attempt to assess pesticides and other environmental contaminants face many challenges of how to measure them, such as, the remoteness of sites and subsequently the difficulty of transportation and stability of chemicals in samples from these sites.  The Sahel region of Western Africa has many highly engineered agriculture-based irrigated systems that generally have three cropping cycles per year.  The need to assess changes in contaminants at these sites requires tools that can characterize contaminants at high spatial and temporal resolution.  Modification of farming pest management practices face the challenge of how to measure success; how to assess the changes in bioavailability of contaminants.  They need quantitative tools that can characterize contaminants and predict their risk to local organisms and humans.  To address these issues we have further developed passive sampling devices (PSDs) that can sequester thousands of bioavailable chemicals.  These devices can help organizations and developing countries to evaluate changes in pest management that may produce or release chemicals.  PSDs can help organizers characterize exposure more accurately.  We are using PSDs to capture relevant non-polar and semi-polar pesticides and other chemicals of interest at multiple sites in Western Africa.  PSDs do not require power, transport easily and are easily extracted with organic solvent. We deployed PSDs in irrigation canals at seven agricultural sites in Senegal, Mali, and Mauritania agricultural stations. We were able to screen the PSD extracts for nearly 1,200 potential contaminants with gas chromatography mass spectrometry through the use  of libraries we have further developed based on software, including automated compiled mass spectral de-convolution and identification system libraries that contain numerous classes of chemicals of concern (pesticides, PCBs, PAHs, pharmaceuticals, industrially related chemicals, etc.). The results for all sites combined showed positive hits of six PCB congeners, 11 pesticides, 21 PAHs and two legacy pesticides including ethiolate, p’p’ DDD and its breakdown products.  Furthermore the compound pentachloroanisole a breakdown product of pentachlorophenol was detected in Mauritania. PSDs coupled with GC-MS screening tools offer a powerful technology to identify persistent organic pollutants present at agricultural sites in three countries in the Sahel region of Western Africa. 

%B SETAC North America 33rd Annual Meeting %8 11/2012 %G eng %0 Audiovisual Material %D 2008 %T Overcoming the Technical Challenges of an International Human and Eological Health Risk Project in Western Africa. Part 2: Integrating Quality Assurance and Trace Pesticide Analysis Between Laboratories %A Hillwalker, Wendy E %A Gregory J Sower %A Ackerman, Amanda %A Quarles, L %A Jeffrey J Jenkins %A Fall, N %A Ndieye, A. %A Sarr, Makhfousse %A Kim A Anderson %B The Society for Environmental Toxicology and Chemistry. North America Annual Meeting, Tampa, FL, USA %8 11/2008 %G eng