%0 Journal Article %J J Expo Sci Environ Epidemiol %D 2024 %T Predicting personal PAH exposure using high dimensional questionnaire and wristband data. %A McLarnan, Sarah M %A Lisa M Bramer %A Holly Dixon %A Richard P Scott %A Lehyla Calero %A Darrell Holmes %A Gibson, Elizabeth A %A Cavalier, Haleigh M %A Diana Rohlman %A Miller, Rachel L %A Laurel D Kincl %A Katrina M Waters %A Kim A Anderson %A Julie Herbstman %X

BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs) are a class of pervasive environmental pollutants with a variety of known health effects. While significant work has been completed to estimate personal exposure to PAHs, less has been done to identify sources of these exposures. Comprehensive characterization of reported sources of personal PAH exposure is a critical step to more easily identify individuals at risk of high levels of exposure and for developing targeted interventions based on source of exposure.

OBJECTIVE: In this study, we leverage data from a New York (NY)-based birth cohort to identify personal characteristics or behaviors associated with personal PAH exposure and develop models for the prediction of PAH exposure.

METHODS: We quantified 61 PAHs measured using silicone wristband samplers in association with 75 questionnaire variables from 177 pregnant individuals. We evaluated univariate associations between each compound and questionnaire variable, conducted regression tree analysis for each PAH compound and completed a principal component analysis of for each participant's entire PAH exposure profile to determine the predictors of PAH levels.

RESULTS: Regression tree analyses of individual compounds and exposure mixture identified income, time spent outdoors, maternal age, country of birth, transportation type, and season as the variables most frequently predictive of exposure.

%B J Expo Sci Environ Epidemiol %8 2024 Jan 05 %G eng %R 10.1038/s41370-023-00617-y %0 Journal Article %J Environ Int %D 2022 %T Evaluating predictive relationships between wristbands and urine for assessment of personal PAH exposure. %A Holly Dixon %A Lisa M Bramer %A Richard P Scott %A Lehyla Calero %A Darrell Holmes %A Gibson, Elizabeth A %A Cavalier, Haleigh M %A Diana Rohlman %A Miller, Rachel L %A Antonia M Calafat %A Laurel D Kincl %A Katrina M Waters %A Julie Herbstman %A Kim A Anderson %X

During events like the COVID-19 pandemic or a disaster, researchers may need to switch from collecting biological samples to personal exposure samplers that are easy and safe to transport and wear, such as silicone wristbands. Previous studies have demonstrated significant correlations between urine biomarker concentrations and chemical levels in wristbands. We build upon those studies and use a novel combination of descriptive statistics and supervised statistical learning to evaluate the relationship between polycyclic aromatic hydrocarbon (PAH) concentrations in silicone wristbands and hydroxy-PAH (OH-PAH) concentrations in urine. In New York City, 109 participants in a longitudinal birth cohort wore one wristband for 48 h and provided a spot urine sample at the end of the 48-hour period during their third trimester of pregnancy. We compared four PAHs with the corresponding seven OH-PAHs using descriptive statistics, a linear regression model, and a linear discriminant analysis model. Five of the seven PAH and OH-PAH pairs had significant correlations (Pearson's r = 0.35-0.64, p ≤ 0.003) and significant chi-square tests of independence for exposure categories (p ≤ 0.009). For these five comparisons, the observed PAH or OH-PAH concentration could predict the other concentration within a factor of 1.47 for 50-80% of the measurements (depending on the pair). Prediction accuracies for high exposure categories were at least 1.5 times higher compared to accuracies based on random chance. These results demonstrate that wristbands and urine provide similar PAH exposure assessment information, which is critical for environmental health researchers looking for the flexibility to switch between biological sample and wristband collection.

%B Environ Int %V 163 %P 107226 %8 2022 Apr 04 %G eng %R 10.1016/j.envint.2022.107226 %0 Audiovisual Material %D 2020 %T Silicone Pet Tags Associate Tris(1,3-Dichloro-2-Isopropyl) Phosphate Exposures with Feline Hyperthyroidism %A Carolyn M Poutasse %A Julie Herbstman %A Mark E Peterson %A Jana Gordon %A Peter Soboroff %A Darrell Holmes %A Dezere Gonzalez %A Lane G Tidwell %A Kim A Anderson %B 10th Annual OSU EMT Research Day, Corvallis, OR %8 1/2020 %G eng %0 Journal Article %J Chemosphere %D 2019 %T Differential exposure to organophosphate flame retardants in mother-child pairs. %A Gibson, Elizabeth A %A Heather M Stapleton %A Lehyla Calero %A Darrell Holmes %A Burke, Kimberly %A Martinez, Rodney %A Cortes, Boris %A Nematollahi, Amy %A Evans, David %A Kim A Anderson %A Julie Herbstman %K Adult %K Child %K Child Development %K Child, Preschool %K Cohort Studies %K Dust %K Environmental Exposure %K Female %K Flame Retardants %K Humans %K Male %K Mothers %K Organophosphates %K Young Adult %X

BACKGROUND: Humans are ubiquitously exposed to flame retardants, including organophosphate esters (OPEs), through direct contact with consumer products or exposure through household dust. Children are at increased risk because of their proximity to dust, hand-to-mouth activity, and the importance of childhood as a critical period in neurodevelopment.

OBJECTIVES: To quantify differences in exposure levels between mothers and children (three to six years of age), we analyzed urinary metabolites of OPEs. We additionally assessed the ability of silicone wristbands (measuring ambient exposure) to predict urinary metabolite concentrations.

METHODS: We selected 32 mother and child dyads from an existing cohort. Participants provided baseline urine samples and wore wristbands for one week. After the first week, they returned their wristbands and provided a second urine sample. During the second week, participants wore a second wristband that they returned at the end of week two with a third and final urine sample.

RESULTS: We found significantly higher levels of bis(1,3-dichloro-2-propyl) phosphate (BDCIPP) (p < 0.001) and lower levels of bis(1-chloro-2-isopropyl) 1-hydroxy-2-propyl phosphate (BCIPHIPP) (p < 0.001) in children's urine samples compared to mothers' samples at baseline. We found that triphenylphosphate (TPHP), tris(1,3-dichloroisopropyl) phosphate (TDCIPP), and tris(1-chloro-2-propyl) phosphate (TCIPP) measured in wristbands predicted their respective metabolite levels in urine.

CONCLUSION: Children had higher levels than mothers for two of six flame retardant metabolites measured in urine. Generally, wristband measurements positively predicted internal dose. As little is known about the health effects of OPEs on child development, future research is needed to determine the impact of differential exposure.

%B Chemosphere %V 219 %P 567-573 %8 2019 Mar %G eng %R 10.1016/j.chemosphere.2018.12.008 %0 Generic %D 2019 %T NIEHS Extramural Paper of the Month: Flame retardant linked to hyperthyroidism in cats %A Carolyn M Poutasse %A Julie Herbstman %A Mark E Peterson %A Jana Gordon %A Peter Soboroff %A Darrell Holmes %A Dezere Gonzalez %A Lane G Tidwell %A Kim A Anderson %B National Institute of Environmental Health Sciences, https://factor.niehs.nih.gov/2019/9/papers/dert/index.htm %8 09/2019 %G eng %U https://factor.niehs.nih.gov/2019/9/papers/dert/index.htm %0 Generic %D 2019 %T SETAC Best Student Platform Award (3rd Place): Foster (Sonny) Mayer PhD Category %A Carolyn M Poutasse %A Julie Herbstman %A Mark E Peterson %A Jana Gordon %A Peter Soboroff %A Darrell Holmes %A Dezere Gonzalez %A Lane G Tidwell %A Kim A Anderson %B SETAC North America 40th Annual Meeting, Toronto, ON %8 11/2019 %G eng %U https://awards.setac.org/best-student-presentation/ %0 Journal Article %J Environ Sci Technol %D 2019 %T Silicone Pet Tags Associate Tris(1,3-dichloro-2-isopropyl) Phosphate Exposures with Feline Hyperthyroidism. %A Carolyn M Poutasse %A Julie Herbstman %A Mark E Peterson %A Jana Gordon %A Peter Soboroff %A Darrell Holmes %A Dezere Gonzalez %A Lane G Tidwell %A Kim A Anderson %K Animals %K Cats %K Flame Retardants %K Halogenated Diphenyl Ethers %K Hyperthyroidism %K New York %K Oregon %K Organophosphates %K Phosphates %K Silicones %X

Feline hyperthyroidism is the most commonly diagnosed endocrine-related disease among senior and geriatric housecats, but the causes remain unknown. Exposure to endocrine-disrupting compounds with thyroid targets, such as flame retardants (FRs), may contribute to disease development. Silicone passive sampling devices, or pet tags, quantitatively assessed the bioavailable FR exposures of 78 cats (≥7 y) in New York and Oregon using gas chromatography-mass spectrometry. Pet tags were analyzed for 36 polybrominated diphenyl ethers, six organophosphate esters (OPEs), and two alternative brominated FRs. In nonhyperthyroid cats, serum free thyroxine (fT), total T (TT), total triiodothyronine, and thyroid-stimulating hormone concentrations were compared with FR concentrations. Tris(1,3-dichloro-2-isopropyl) phosphate (TDCIPP) concentrations were higher in hyperthyroid pet tags in comparison to nonhyperthyroid pet tags (adjusted odds ratio, < 0.07; Mantel-Cox, < 0.02). Higher TDCIPP concentrations were associated with air freshener use in comparison to no use ( < 0.01), residences built since 2005 compared to those pre-1989 ( < 0.002), and cats preferring to spend time on upholstered furniture in comparison to no preference ( < 0.05). Higher TDCIPP concentrations were associated with higher fT and TT concentrations ( < 0.05). This study provides proof-of-concept data for the use of silicone pet tags with companion animals and further indicates that bioavailable TDCIPP exposures are associated with feline hyperthyroidism.

%B Environ Sci Technol %V 53 %P 9203-9213 %8 2019 Aug 06 %G eng %N 15 %R 10.1021/acs.est.9b02226 %0 Generic %D 2019 %T Silicone Pet Tags Associate Tris(1,3-Dichloro-2-Isopropyl) Phosphate Exposures with Feline Hyperthyroidism %A Carolyn M Poutasse %A Julie Herbstman %A Mark E Peterson %A Jana Gordon %A Peter Soboroff %A Darrell Holmes %A Dezere Gonzalez %A Lane G Tidwell %A Kim A Anderson %B SETAC North America 40th Annual Meeting, Toronto, ON %8 11/2019 %G eng %0 Generic %D 2019 %T Silicone Pet Tags Associate Tris(1,3-Dichloro-2-Isopropyl) Phosphate Exposures with Feline Hyperthyroidism %A Carolyn M Poutasse %A Julie Herbstman %A Mark E Peterson %A Jana Gordon %A Peter Soboroff %A Darrell Holmes %A Dezere Gonzalez %A Lane G Tidwell %A Kim A Anderson %B Oregon State University, Environmental Health Science Center July Colloquium, Corvallis, OR %8 07/2019 %G eng %0 Audiovisual Material %D 2018 %T Silicone Cat Tags Detect Feline Flame Retardant Exposures %A Carolyn M Poutasse %A Julie Herbstman %A Mark E Peterson %A Jana Gordon %A Peter Soboroff %A Darrell Holmes %A Dezere Gonzalez %A Lane G Tidwell %A Kim A Anderson %B Joint Meeting of the International Society of Exposure Science and International Society of Environmental Epidemiology, Ottawa, ON %8 08/2018 %G eng %0 Audiovisual Material %D 2018 %T Silicone Cat Tags Detect Feline Flame Retardant Exposures %A Carolyn M Poutasse %A Julie Herbstman %A Mark E Peterson %A Jana Gordon %A Peter Soboroff %A Darrell Holmes %A Dezere Gonzalez %A Lane G Tidwell %A Kim A Anderson %B OSU Superfund Research Program External Advisory Council Meeting, Carson, WA %8 03/2018 %G eng %0 Journal Article %J Anal Bioanal Chem %D 2018 %T Silicone wristbands compared with traditional polycyclic aromatic hydrocarbon exposure assessment methods %A Holly Dixon %A Richard P Scott %A Darrell Holmes %A Lehyla Calero %A Laurel D Kincl %A Katrina M Waters %A David Camann %A Antonia M Calafat %A Julie Herbstman %A Kim A Anderson %X

Currently there is a lack of inexpensive, easy-to-use technology to evaluate human exposure to environmental chemicals, including polycyclic aromatic hydrocarbons (PAHs). This is the first study in which silicone wristbands were deployed alongside two traditional personal PAH exposure assessment methods: active air monitoring with samplers (i.e., polyurethane foam (PUF) and filter) housed in backpacks, and biological sampling with urine. We demonstrate that wristbands worn for 48 h in a non-occupational setting recover semivolatile PAHs, and we compare levels of PAHs in wristbands to PAHs in PUFs-filters and to hydroxy-PAH (OH-PAH) biomarkers in urine. We deployed all samplers simultaneously for 48 h on 22 pregnant women in an established urban birth cohort. Each woman provided one spot urine sample at the end of the 48-h period. Wristbands recovered PAHs with similar detection frequencies to PUFs-filters. Of the 62 PAHs tested for in the 22 wristbands, 51 PAHs were detected in at least one wristband. In this cohort of pregnant women, we found more significant correlations between OH-PAHs and PAHs in wristbands than between OH-PAHs and PAHs in PUFs-filters. Only two comparisons between PAHs in PUFs-filters and OH-PAHs correlated significantly (r = 0.53 and p = 0.01; r = 0.44 and p = 0.04), whereas six comparisons between PAHs in wristbands and OH-PAHs correlated significantly (r = 0.44 to 0.76 and p = 0.04 to <0.0001). These results support the utility of wristbands as a biologically relevant exposure assessment tool which can be easily integrated into environmental health studies. Graphical abstract PAHs detected in samples collected from urban pregnant women.

%B Anal Bioanal Chem %8 04/2018 %G eng %R 10.1007/s00216-018-0992-z %0 Audiovisual Material %D 2018 %T Silicone wristbands compared with traditional polycyclic aromatic hydrocarbon exposure assessment methods %A Holly Dixon %A Richard P Scott %A Darrell Holmes %A Lehyla Calero %A Laurel D Kincl %A Katrina M Waters %A David Camann %A Antonia M Calafat %A Julie Herbstman %A Kim A Anderson %B 3rd Tribal Environmental Health Summit, Corvallis, OR %C Corvallis, Oregon %8 06/2018 %G eng %0 Generic %D 2018 %T Wearable Silicone Passive Sampling Devices Explore Flame Retardant Exposures in Hyperthyroid Housecat Case-Control Study %A Carolyn M Poutasse %A Julie Herbstman %A Mark E Peterson %A Jana Gordon %A Peter Soboroff %A Darrell Holmes %A Dezere Gonzalez %A Lane G Tidwell %A Kim A Anderson %B Joint Meeting of the International Society of Exposure Science and International Society of Environmental Epidemiology, Ottawa, ON %8 08/2018 %G eng %0 Audiovisual Material %D 2018 %T Wearable Silicone Passive Sampling Devices Reveal Flame Retardant Exposures in Case-Control Housecat Study %A Carolyn M Poutasse %A Julie Herbstman %A Mark E Peterson %A Jana Gordon %A Peter Soboroff %A Darrell Holmes %A Dezere Gonzalez %A Lane G Tidwell %A Kim A Anderson %B 3rd Tribal Environmental Health Summit, Corvallis, OR %8 06/2018 %G eng %0 Audiovisual Material %D 2017 %T Assessing PAH exposures with multiple approaches including silicone wristbands %A Holly Dixon %A Richard P Scott %A Darrell Holmes %A Lehyla Calero %A Laurel D Kincl %A Katrina M Waters %A David Camann %A Julie Herbstman %A Kim A Anderson %B EMT Research Day %C Corvallis, OR %8 01/2017 %G eng %0 Audiovisual Material %D 2016 %T Assessing PAH exposures with multiple approaches including silicone wristbands %A Holly Dixon %A Richard P Scott %A Darrell Holmes %A Lehyla Calero %A Laurel D Kincl %A Katrina M Waters %A David Camann %A Julie Herbstman %A Kim A Anderson %B NIEHS 50th Anniversary FEST, Durham, North Carolina %8 2016 %G eng %0 Generic %D 2016 %T Assessing PAH exposures with multiple approaches including silicone wristbands %A Holly Dixon %A Richard P Scott %A Darrell Holmes %A Lehyla Calero %A Laurel D Kincl %A Katrina M Waters %A David Camann %A Antonia M Calafat %A Julie Herbstman %A Kim A Anderson %B International Society of Exposure Science 26th Annual Meeting, Utrecht, Netherlands %8 10/2016 %G eng