%0 Journal Article %J Toxicology %D 2012 %T Neurodevelopmental low-dose bisphenol A exposure leads to early life-stage hyperactivity and learning deficits in adult zebrafish. %A Saili, Katerine S %A Corvi, Margaret M %A Weber, Daniel N %A Patel, Ami U %A Das, Siba R %A Przybyla, Jennifer %A Kim A Anderson %A Robyn L Tanguay %K Animals %K Behavior, Animal %K Benzhydryl Compounds %K Chromatography, High Pressure Liquid %K Dose-Response Relationship, Drug %K Embryo, Nonmammalian %K Endocrine Disruptors %K Environmental Pollutants %K Estradiol %K Hydrazines %K Hyperkinesis %K Larva %K Learning Disorders %K Maze Learning %K Phenols %K Receptors, Estrogen %K Receptors, G-Protein-Coupled %K Reversal Learning %K Teratogens %K Zebrafish %X

Developmental bisphenol A (BPA) exposure has been implicated in adverse behavior and learning deficits. The mode of action underlying these effects is unclear. The objectives of this study were to identify whether low-dose, developmental BPA exposure affects larval zebrafish locomotor behavior and whether learning deficits occur in adults exposed during development. Two control compounds, 17β-estradiol (an estrogen receptor ligand) and GSK4716 (a synthetic estrogen-related receptor gamma ligand), were included. Larval toxicity assays were used to determine appropriate BPA, 17β-estradiol, and GSK4716 concentrations for behavior testing. BPA tissue uptake was analyzed using HPLC and lower doses were extrapolated using a linear regression analysis. Larval behavior tests were conducted using a ViewPoint Zebrabox. Adult learning tests were conducted using a custom-built T-maze. BPA exposure to <30μM was non-teratogenic. Neurodevelopmental BPA exposure to 0.01, 0.1, or 1μM led to larval hyperactivity or learning deficits in adult zebrafish. Exposure to 0.1μM 17β-estradiol or GSK4716 also led to larval hyperactivity. This study demonstrates the efficacy of using the zebrafish model for studying the neurobehavioral effects of low-dose developmental BPA exposure.

%B Toxicology %V 291 %P 83-92 %8 01/2012 %G eng %N 1-3 %1 http://www.ncbi.nlm.nih.gov/pubmed/22108044?dopt=Abstract %R 10.1016/j.tox.2011.11.001